S193

Anti-Synapsin I antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonym(s): Anti-EPILX, Anti-MRX50, Anti-SYN1a, Anti-SYN1b, Anti-SYNI
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD00282157
• Conjugate: unconjugated
• Clone: polyclonal
• Application: DB, IF, IHC (f), IP, WB
• Citations: 36

Properties

• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• mol wt: antigen ~80 kDa (Synapsin Ia)
• species reactivity: rat, mouse, human, bovine
• technique(s): dot blot: 1:1000, immunohistochemistry (frozen sections): 1:2000, immunoprecipitation (IP): 1 μg, indirect immunofluorescence: 1:2000, western blot: 1:1000
• UniProt accession no.: P17600
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SYN1(6853) ; mouse ... Syn1(20964) ; rat ... Syn1(24949)

Description

General description

Synapsin I (1a and 1b) refers to two nearly identical phosphoproteins found in the cytoplasmic surface of synaptic vesicles of the CNS (central nervous system) and PNS(peripheral nervous system). It may be used to localize and detect synapsin I (synapsins Ia and Ib are collectively referred to as synapsin I) in nerve terminals.The SYN1 gene is mapped to human chromosome Xp11.3-p11.23.

Immunogen

synapsin I from bovine brain.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.

• Western Blotting (1 paper)
• immunohistochemistry
• immunoblotting
• immunoprecipitation
• ELISA.

Rabbit polyclonal anti-Synapsin I antibody can be used for the localization and detection of synapsin I (synapsins Ia and Ib, approximately 80 kDa and 77 kDa, are collectively referred to as synapsin I) in nerve terminals.

Biochem/physiol Actions

Synapsin I is involved in the regulation of axonogenesis and synaptogenesis wherein it serves as a substrate of various protein kinases including those activated by cAMP, calciuim/calmodulin, mitogens, and cyclins. The antibody strongly reacts with the synapsin I doublet. Synapsin I is associated with vesicle trafficking. Mutation in this gene is one of the known cause for familial epilepsy and autism spectrum disorders.

Physical form

Lyophilized from ammonium bicarbonate (5 mM)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• WGK: WGK 2
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)