RAB0402

Human Platelet Factor-4 / CXCL4 ELISA Kit

for serum, plasma, cell culture supernatant and urine

• Synonym(s): C-X-C motif chemokine 4, Oncostatin-A, PF-4, Platelet factor 4, PF4
• NACRES: NA.32
• UNSPSC Code: 41116158
• Gene information: human ... PF4(5196)
• Input: sample type serum; sample type plasma; sample type urine; sample type cell culture supernatant(s)
• Species reactivity: human
• Storage temp.: −20°C
• Shipped in: wet ice

Properties

• species reactivity: human
• packaging: kit of 96 wells (12 strips x 8 wells)
• technique(s): ELISA: suitable, capture ELISA: suitable
• input: sample type serum; sample type plasma; sample type urine; sample type cell culture supernatant(s)
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 20 pg/mL; standard curve range: 20.58-15000 pg/mL
• detection method: colorimetric
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... PF4(5196)

Description

General description

The Human PF-4 (Platelet Factor-4) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human PF-4 in serum, plasma, cell culture supernatants and urine.

Immunogen

Recombinant Human PF4

Application

For research use only. Not for use in diagnostic procedures.
Human Platelet Factor-4 (PF4)/ CXCL4 (chemokine (C-X-C motif) ligand 4) ELISA Kit has been used to measure PF-4 / CXCL4 serum level in chronic myelomonocytic leukemia (CMML) patients.

Human Platelet Factor-4 / CXCL4 ELISA Kit has also been used in the measurement of platelet factor-4 in serum samples of prostate cancer and pseudoxanthoma elasticum patients.

Biochem/physiol Actions

Platelet factor-4 (PF-4) or chemokine (C-X-C motif) ligand 4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. This protein associates with heparin and neutralizes it. It also neutralizes various other negatively charged proteoglycans. PF-4 / CXCL4 is implicated in cancer development. PF-4 regulates the activity of proangiogenic growth factors. PF-4 / CXCL4 function as a biomarker for systemic sclerosis and early tumor growth. PF-4 / CXCL4 is associated with various pathological conditions such as atherosclerosis, liver fibrosis and inflammation.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Kit Components Also Available Separately

• RABELADB

  ELISA 5X Assay/Sample Diluent Buffer B (Item E1)

  SDS
• RABELADC

  ELISA 1X Assay/Sample Diluent Buffer C (Item L)

  SDS
• RABSTOP3

  ELISA Stop Solution (Item I)

  SDS
• RABTMB3

  ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)

  SDS
• RABWASH4

  20X Wash Buffer (Item B)

  SDS

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Codes: H334
• Storage Class: 10 - Combustible liquids
• Precautionary Statements: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1