R108

Ro 41-0960

solid

• Synonym(s): 2′-Fluoro-3,4-dihydroxy-5-nitrobenzophenone
• Empirical Formula (Hill Notation): C₁₃H₈FNO₅
• CAS Number: 125628-97-9
• Molecular Weight: 277.20
• NACRES: NA.77
• PubChem Substance ID: 24278193
• UNSPSC Code: 12352200
• MDL number: MFCD00078597
• Form: solid
• Storage condition: protect from light

Properties

• form: solid
• Quality Segment: 100
• storage condition: protect from light
• color: yellow
• solubility: H₂O: slightly soluble <0.7 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0 mg/mL, ethanol: soluble
• storage temp.: 2-8°C
• SMILES string: Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F
• InChI: 1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H
• InChI key: RQPAUNZYTYHKHA-UHFFFAOYSA-N
• Gene Information: human ... COMT(1312)

Description

Application

Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations [1] and 3T3-L1 adipocytes.[2] It has also been used as a catechol-O-methyl-transferase inhibitor to treat corpus striatum samples to test its effect on dopamine metabolism.[3]

Biochem/physiol Actions

Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT).[4] It binds to the catalytic site and triggers the inhibition of the methylation property of COMT.[5] Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids.[4]

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Store tightly sealed at 4 °C, protected from exposure to light.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)