Q3638

Quetiapine hemifumarate salt

≥98% (HPLC), serotonin (5HT2) and dopamine (D2) receptor antagonist, powder

• Synonym(s): 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate, Quetiapine fumarate
• Empirical Formula (Hill Notation): C₂₁H₂₅N₃O₂S · 0.5C₄H₄O₄
• CAS Number: 111974-72-2
• Molecular Weight: 441.54
• UNSPSC Code: 12352200
• PubChem Substance ID: 329823864
• NACRES: NA.77
• MDL number: MFCD03423782
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: Quetiapine hemifumarate salt, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: >10 mg/mL
• originator: AstraZeneca
• storage temp.: 2-8°C
• SMILES string: OC(=O)\C=C\C(O)=O.OCCOCCN1CCN(CC1)C2=Nc3ccccc3Sc4ccccc24.OCCOCCN5CCN(CC5)C6=Nc7ccccc7Sc8ccccc68
• InChI: 1S/2C21H25N3O2S.C4H4O4/c2*25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21;5-3(6)1-2-4(7)8/h2*1-8,25H,9-16H2;1-2H,(H,5,6)(H,7,8)/b;;2-1+
• InChI key: ZTHJULTYCAQOIJ-WXXKFALUSA-N
• Gene Information: human ... DRD2(1813), HTR2A(3356), HTR2C(3358)

Description

General description

Quetiapine is a derivative of dibenzothiazepine compound[1] and is also referred to as seroquel and clemastine.

Application

Quetiapine hemifumarate salt has been used as an antagonist for β-arrestin 2 mutant T205M recruitment.[2]

Biochem/physiol Actions

Quetiapine promotes oligodendrogenesis in vitro. It is used in treating depressive disorders.[1]

Quetiapine hemifumarate is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist.

Quetiapine hemifumarate is an atypical antipsychotic, a combined serotonin (5HT2) and dopamine (D2) receptor antagonist.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302,H400
• pcodes: P273 - P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable