PLA0204

Rabbit anti-cAbl Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• Synonym(s): ABL, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, JTK7, bcr/abl, bcr/c-abl oncogene protein, c-ABL, c-ABL1, c-abl oncogene 1, non-receptor tyrosine kinase, p150, proto-oncogene c-Abl, proto-oncogene tyrosine-protein kinase ABL1, receptor tyrosine kinase, v-abl, v-abl Abelson murine leukemia viral oncogene homolog 1
• NACRES: NA.41
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IF, IHC, IP
• Citations: -

Properties

• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• clone: polyclonal
• species reactivity: human
• technique(s): immunofluorescence: 1:500- 1:2,000, immunohistochemistry: 1:500- 1:2,000, immunoprecipitation (IP): 2- 5 μg/mg
• accession no.: NP_005148.2
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: rabbit ... cAbl(25)

Description

Immunogen

The epitope recognized by PLA0204 maps to a region between residue 850 and 900 of human v-abl Abelson murine leukemia viral oncogene homolog 1 using the numbering given in entry NP_005148.2 (GeneID 25).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

c-Abl is the human cellular homolog of a the v-Abl viral oncogene. v-Abl was originally discovered as a mouse cell-derived sequence in the genome of the Abelson murine leukemia virus (A-MuLV), a transforming retrovirus isolated by the laboratory of Dr. H.T. Abelson. c-Abl is a tyrosine kinase from the Src-family of tyrosine kinases that localizes to both the cytoplasm and nucleus. It bears an SH2 (src-homology 2) and SH3 (src-homology 3) domain responsible for mediating c-Abl protein-protein interactions. c-Abl is implicated to play a role in multiple cellular processes such as cell cycle checkpoint signaling, apoptosis, cell differentiation, cell adhesion, and transcriptional regulation. Chromosomal translocations involving the c-Abl gene are associated with human leukemias.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable