P6249

p53 human

recombinant, expressed in E. coli, buffered aqueous glycerol solution

• NACRES: NA.25
• UNSPSC Code: 12352202
• Form: buffered aqueous glycerol solution
• Assay: ≥90% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in E. coli

Properties

• biological source: human
• Quality Segment: 200
• recombinant: expressed in E. coli
• assay: ≥90% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• UniProt accession no.: P04637
• application(s): genomic analysis
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... TP53(7157)

Description

General description

p53 is regulated by MDM2, which acts as a negative regulator of p53 transcription by promoting its degradation by functioning as an E3 ubiquitin ligase which recognizes the N′ terminal transactivation domain.

GST-tagged, full-length human p53

Application

Useful for the study of postranslational modification of p53, or protein-protein interaction studies.

Biochem/physiol Actions

p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.

Safety Information

• Storage Class: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable