This product is not tested for activity on a lot to lot basis. However, historical data show a range of 0.01 - 0.03 units per milligram.
P4506
Phosphodiesterase I from Crotalus atrox (Western Diamondback Rattlesnake)
Type IV, crude dried venom
Synonym(s):
5′-Exonuclease, Oligonucleate 5′-nucleotidohydrolase
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100 MG
CZK 2,150.00
500 MG
CZK 5,208.00
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100 MG
CZK 2,150.00
500 MG
CZK 5,208.00
About This Item
EC Number:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54
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General description
Research area: Cell signalingPhosphodiesteraseI (PDEI) exists in three isoforms PDE1A,PDE1B, and PDE1C(2) that are locatedin cardiovascular, central nervous system, and other organs.[1]
Application
Phosphodiesterase I from Crotalus atrox (Western Diamondback Rattlesnake) has been used to analyse its effect on intracellular calcium concentration of neutrophils.[2] It has also been used in combination with other enzymes to determine the activity of phosphatase enzyme.[3]
Phosphodiesterase I, product P4506 from western diamondback rattlesnake, is used in phosphodiesterase activation assays for calmodulin. It is added to hydrolyze AMP[4].
Biochem/physiol Actions
Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates[4][5]. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C[6]. Phosphodiesterase I (PDEI) can hydrolyze 3′,5′-cyclicadenosine monophosphate (cAMP) and 3′,5′-cyclic guanosine monophosphate (cGMP).It forms a complex with Ca2+/calmodulin (CaM) that leads to the activationof its catalytic activity.PDEIshows biotherapeutic effects for the treatment of cancer, diseases, neurocognitive,pulmonary, metabolic, heart, renal, neurological disorders, and endocrineabnormalities.[1]
inhibitor
Product No.
Description
Pricing
substrate
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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