P0689

(R)-(+)-Propranolol hydrochloride

≥98% (TLC), Beta-adrenergic antagonist

• Synonym(s): Propranolol HCl, (R)-1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride
• Linear Formula: C₁₀H₇OCH₂CH(OH)CH₂NHCH(CH₃)₂·HCl
• CAS Number: 13071-11-9
• Molecular Weight: 295.80
• NACRES: NA.77
• PubChem Substance ID: 24898124
• UNSPSC Code: 12352200
• EC Number: 235-961-7
• MDL number: MFCD00064546
• Beilstein/REAXYS Number: 5780490
• Assay: ≥98% (TLC)

Properties

• Product Name: (R)-(+)-Propranolol hydrochloride, ≥98% (TLC)
• Quality Segment: 200
• assay: ≥98% (TLC)
• mp: 196-198 °C (lit.)
• solubility: ethanol: 10 mg/mL, DMSO: <14.5 mg/mL, H₂O: 50 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
• originator: AstraZeneca
• storage temp.: 2-8°C
• SMILES string: Cl.CC(C)NC[C@@H](O)COc1cccc2ccccc12
• InChI: 1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H/t14-;/m1./s1
• InChI key: ZMRUPTIKESYGQW-PFEQFJNWSA-N

Description

General description

With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.

Biochem/physiol Actions

Less active enantiomer of propranolol.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves