P0049

Pyronaridine tetraphosphate

• Synonym(s): 2-Methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′-hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine tetraphosphate
• Empirical Formula (Hill Notation): C₂₉H₃₂ClN₅O₂·4H₃PO₄
• CAS Number: 76748-86-2
• Molecular Weight: 910.03
• NACRES: NA.85
• PubChem Substance ID: 329819999
• UNSPSC Code: 51102911
• MDL number: MFCD05863545

Properties

• form: solid
• antibiotic activity spectrum: parasites
• mode of action: enzyme | interferes
• storage temp.: 2-8°C
• SMILES string: OP(O)(O)=O.OP(O)(O)=O.OP(O)(O)=O.OP(O)(O)=O.COc1ccc2nc3cc(Cl)ccc3c(Nc4cc(CN5CCCC5)c(O)c(CN6CCCC6)c4)c2n1
• InChI: 1S/C29H32ClN5O2.4H3O4P/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35;4*1-5(2,3)4/h6-9,14-16,36H,2-5,10-13,17-18H2,1H3,(H,31,32);4*(H3,1,2,3,4)
• InChI key: YKUQEKXHQFYULM-UHFFFAOYSA-N

Description

Application

Pyronaridine, an acridine derivative, is used in China as a treatment for drug-resistant falciparum malaria[1]. It′s in vitro activities have been studied against Plasmodium falciparum in Cameroon[2].

Biochem/physiol Actions

Pyronaridine has antimalarial activity and is used in conjunction with artensunate. It is antagonistic against naphthoquine and dihydroartemisinin. Pyronaridine blocks B-hematin formation in vitro and has inhibitory activity toward P-glycoprotein mediated drug resistance.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids

Safety Information

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H361
• pcodes: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves