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P0028

Sigma-Aldrich

PSN-375963

≥98% (HPLC)

Synonym(s):

4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine

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About This Item

Empirical Formula (Hill Notation):
C17H23N3O
CAS Number:
388575-52-8
Molecular Weight:
285.38
MDL number:
MFCD01829706
UNSPSC Code:
12352202
PubChem Substance ID:
329819983
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >10 mg/mL

storage temp.

−20°C

SMILES string

CCCCC1CCC(CC1)c2nc(no2)-c3ccncc3

InChI

1S/C17H23N3O/c1-2-3-4-13-5-7-15(8-6-13)17-19-16(20-21-17)14-9-11-18-12-10-14/h9-13,15H,2-8H2,1H3

InChI key

OAVLEYPTWABFLF-UHFFFAOYSA-N

Biochem/physiol Actions

PSN-375963 is a GPR119 partial agonist.
PSN-375963 is a GPR119 partial agonist. GPR119 is an orphan GPCR, expressed predominantly in pancreas and GI tract, that has been characterized. Its endogenous ligands are oleoylethanolamide (OEA) and oleoyl-lysophosphatidylcholine, lipid signaling molecules that regulate food intake and body weight. OEA decreases food intake, so GPR119 agonists are potential therapies for obesity. Initial studies showed that PSN-375963 has similar potency and partial efficacy compared to OEA. Further studies revealed that although OEA and PSN-375963 are GPR119 agonists, they have divergent effects on insulin secretion, calcium signaling, and cAMP production.

Storage Class Code

11 - Combustible Solids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
119K4712

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Madusha Peiris et al.
Nutrients, 10(10) (2018-10-20)
Nutrient-sensing receptors located on enteroendocrine (EEC) cells modulate appetite via detection of luminal contents. Colonic 'tasting' of luminal contents may influence changes to appetite observed in obesity and after weight loss induced by bariatric surgery. We assessed the effects of

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