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O9639

Oridonin

≥98% (HPLC), Apoptosis inducer, solid

Synonym(s):

7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one, Isodonol

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
CZK 3,470.00
25 mg
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CZK 13,900.00
CZK 11,815.00

About This Item

Empirical Formula (Hill Notation):
C20H28O6
CAS Number:
28957-04-2
Molecular Weight:
364.43
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid

CZK 3,470.00

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Product Name

Oridonin, ≥98% (HPLC), solid

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >20 mg/mL, H2O: insoluble

storage temp.

2-8°C

SMILES string

O1[C@]2([C@]43[C@H]([C@]5([C@H]([C@@H]2O)C(CC[C@@H]5O)(C)C)C1)CC[C@H]([C@H]4O)C(=C)C3=O)O

InChI

1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1

InChI key

SDHTXBWLVGWJFT-XKCURVIJSA-N

Biochem/physiol Actions

Oridonin has potent anti-tumor activity. Oridonin targets AE (AML1-ETO) oncoprotein. Exposure to oridonin induces apoptosis in AE-bearing leukemic cells through the activation of intrinsic apoptotic pathway and triggering a caspase-3-mediated degradation of AE at D188. The compound also prolonged the lifespan of C57 mice bearing truncated AE-expressing leukemic cells without side effects like suppression of bone marrow or reduction of body weight of animals, and exerted synergic effects while combined with cytosine arabinoside. Additionally, oridonin inhibited tumor growth in nude mice inoculated with t(8;21)-harboring Kasumi-1 cells.
Oridonin has potent anti-tumor activity; targets AE oncoprotein.

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Oridonin ≥98% (HPLC), solid

Sigma-Aldrich

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Sigma-Aldrich

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TRO 19622 ≥98% (HPLC), solid

Sigma-Aldrich

T3077

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Naloxone methiodide ≥98% (HPLC), solid

Sigma-Aldrich

N129

Naloxone methiodide

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: >20 mg/mL, H2O: insoluble

solubility

DMSO: ≥2 mg/mL, H2O: insoluble

solubility

DMSO: >10 mg/mL

solubility

H2O: >10 mg/mL

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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