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O5761

Sigma-Aldrich

Osteocalcin fragment 1-49 Human

≥94% (HPLC), solid

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500 μG
CZK 20,500.00
1 MG
CZK 59,000.00

CZK 20,500.00

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500 μG
CZK 20,500.00
1 MG
CZK 59,000.00

About This Item

Empirical Formula (Hill Notation):
C269H381N67O82S2
CAS Number:
136461-80-8
Molecular Weight:
5929.43
MDL number:
MFCD03457847
UNSPSC Code:
12352200
NACRES:
NA.32

CZK 20,500.00

Please contact Customer Service for Availability
Request a Bulk Order

Quality Level

200

Assay

≥94% (HPLC)

form

solid

UniProt accession no.

P02818

storage temp.

−20°C

Gene Information

human ... BGLAP(632)

Amino Acid Sequence

Tyr-Leu-Tyr-Gln-Trp-Leu-Gly-Ala-Pro-Val-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Arg-Arg-Gla-Val-Cys-Gla-Leu-Asn-Pro-Asp-Cys-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val [Disulfide Bridge: 23-29]

General description

Bone γ-carboxyglutamate protein (BGLAP) or osteocalcin (OCN) is a non-collagenous bone matrix protein expressed by osteoblasts. It possesses a Gla (γ carboxyglutamate) domain. The gene encoding OCN is localized on human chromosome 1q22.[1][2][3]
Calcium-binding protein found in dentin and possibly other mineralized tissues.

Application

Human osteocalcin fragment 1-49 has been used for the identification and characterization of glycation adducts on osteocalcin. It has also been used to study its effects on the differentiation of mouse myoblast cell line C2C12.[4][5]

Biochem/physiol Actions

Bone γ-carboxyglutamate protein (BGLAP) regulates osteogenic differentiation of mesenchymal stromal cells. It has a role in bone turnover and mineralization. The protein also has a role in energy metabolism. BGLAP may act as a mediator between glucose metabolism and bone tissue.[1][6][7]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000394957
0000313458
0000313458
0000394957
0000358782

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An overview of osteocalcin progress.
Li J
Journal of Bone and Mineral Metabolism, 34(4), 367-379 (2016)
Hua Shen et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(4), 596-605 (2014-10-29)
It is well-established that muscle forces are necessary for bone development as well as proper bone modeling and remodeling. Recent work has also suggested that bone acts as an endocrine organ that can influence the development of other organs. Connexin43
Serum Levels of Osteocalcin and Insulin Resistance in Patients with Impaired Glucose Tolerance or New-Onset Diabetes Mellitus After Liver Transplantation.
Martinez-Diaz-Guerra G
Hormone and Metabolic Research, 48(5), 325-330 (2016)
Identification and characterization of glycation adducts on osteocalcin
Corinne J
Analytical Biochemistry (2017)
Osteocalcin Mediates Biomineralization during Osteogenic Maturation in Human Mesenchymal Stromal Cells
Yu-Tzu Tsao
International Journal of Molecular Sciences, 18(1), 159-159 (2017)
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