O100

Oxotremorine M

muscarinic acetylcholine receptor agonist, solid

• Synonym(s): N,N,N,-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-ammonium iodide, Oxotremorine methiodide
• Empirical Formula (Hill Notation): C₁₁H₁₉IN₂O
• CAS Number: 63939-65-1
• Molecular Weight: 322.19
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277861
• NACRES: NA.77
• MDL number: MFCD00055133
• Form: solid

Properties

• Product Name: Oxotremorine M, solid
• form: solid
• Quality Segment: 200
• color: white
• solubility: H₂O: 24 mg/mL, ethanol: 4.6 mg/mL
• storage temp.: 2-8°C
• SMILES string: [I-].C[N+](C)(C)CC#CCN1CCCC1=O
• InChI: 1S/C11H19N2O.HI/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14;/h6-10H2,1-3H3;1H/q+1;/p-1
• InChI key: VVLMSCJCXMBGDI-UHFFFAOYSA-M
• Gene Information: human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Description

Application

Oxotremorine M has been used as a muscarinic acetylcholine receptor (mAchR) agonist:

• to study its acute effects on the movement of Caenorhabditis elegans[1]
• to treat hippocampal neurons for studying fibroblast growth factor receptor 1 (FGFR1) phosphorylation
• to induce bladder overactivity in rats[2]

Biochem/physiol Actions

Oxotremorine M is a nonselective muscarinic acetylcholine receptor agonist.[3]

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) and Acetylcholine Receptors (Nicotinic) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H300 + H310 + H330
• pcodes: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)