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N8784

Sigma-Aldrich

Norcantharidin

solid

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About This Item

Empirical Formula (Hill Notation):
C8H8O4
CAS Number:
29745-04-8
Molecular Weight:
168.15
MDL number:
MFCD00213361
UNSPSC Code:
12352202
PubChem Substance ID:
24278599
NACRES:
NA.77

form

solid

SMILES string

O=C1OC(=O)C2C3CCC(O3)C12

InChI

1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2

InChI key

JAABVEXCGCXWRR-UHFFFAOYSA-N

Gene Information

human ... PPP2R5A(5525)

General description

Norcantharidin (NCTD) is a demethylated derivative of cantharidin (CTD).[1]

Application

Norcantharidin has been used in primary cell culture and treatment.[2] It has also been used to treat mice inoculated with Huh7 cells subcutaneously.[3]

Biochem/physiol Actions

Norcantharidin is a potential antitumor agent. Norcantharidin helps to block SK-N-SH neuroblastoma cell growth by stimulating autophagy and apoptosis.[1]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
101K1371

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Chung-Hsin Yeh et al.
Chinese journal of integrative medicine, 18(9), 676-682 (2012-09-01)
To investigate the inhibitory activities of norcantharidin (NCTD), a demethylated analogue of cantharidin, on Hep3B cells (a human hepatoma cell line) with deficiency of p53. The survival rate of the Hep3B cells after treating with NCTD was measured by MTT
Min Guan et al.
Nanomedicine : nanotechnology, biology, and medicine, 8(7), 1172-1181 (2012-02-11)
N-Trimethyl chitosan (TMC) was synthesized and used to prepare lactosyl-norcantharidin TMC nanoparticles (Lac-NCTD-TMC-NPs) using an ionic cross-linkage process. Lac-NCTD-TMC-NPs with an average particle size of 120.6 ± 1.7 nm were obtained, with an entrapment efficiency of 69.29% ± 0.76%, and
Yu-Jen Chen et al.
PloS one, 7(5), e37006-e37006 (2012-05-23)
Multi-drug resistance (MDR), an unfavorable factor compromising treatment efficacy of anticancer drugs, involves upregulated ATP binding cassette (ABC) transporters and activated Sonic hedgehog (Shh) signaling. By preparing human breast cancer MCF-7 cells resistant to doxorubicin (DOX), we examined the effect
C Y Hong et al.
Biochemical and biophysical research communications, 276(1), 278-285 (2000-09-28)
Norcantharidin (NCTD), a synthetic analogue of phosphatase type 2A inhibitors, cantharidin, was shown to have limited effects in treating human and animal tumors. The tumor cell killing mechanisms by norcantharidin, however, remain unclear. In this report, we wished to investigate
Norcantharidin modulates the miR-30a/Metadherin/AKT signaling axis to suppress proliferation and metastasis of stromal tumor cells in giant cell tumor of bone
Chen F, et al.
Biomedicine and Pharmacotherapy, 103, 1092-1100 (2018)
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