N8162

NIDA-41020

≥97% (HPLC), solid

• Synonym(s): 1-(2,4-Dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide
• Empirical Formula (Hill Notation): C₂₃H₂₄Cl₂N₄O₂
• CAS Number: 502486-89-7
• Molecular Weight: 459.37
• NACRES: NA.77
• PubChem Substance ID: 329818682
• UNSPSC Code: 12352200
• MDL number: MFCD08277026
• Assay: ≥97% (HPLC)
• Form: solid

Properties

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: solid
• color: off-white
• solubility: DMSO: ~16 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: COc1ccc(cc1)-c2c(C)c(nn2-c3ccc(Cl)cc3Cl)C(=O)NN4CCCCC4
• InChI: 1S/C23H24Cl2N4O2/c1-15-21(23(30)27-28-12-4-3-5-13-28)26-29(20-11-8-17(24)14-19(20)25)22(15)16-6-9-18(31-2)10-7-16/h6-11,14H,3-5,12-13H2,1-2H3,(H,27,30)
• InChI key: KWDBQJRWPWTGPF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development. NIDA-41020 is less lipophilic; developed at NIDA as a potential radioligand for CB₁ receptors, K_i = 4.1 nM [in comparison AM 251, AM 281, SR 141716 (Rimonabant) have K_i of 0.6, 4.5 and 1.8 nM respectively].

NIDA-41020 is a CB₁ cannabinoid receptor antagonist.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Codes: H300,H315,H319,H335
• Precautionary Statements: P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges