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N8028

Nikkomycin Z from Streptomyces tendae

≥90% (HPLC)

Synonym(s):

Neopolyoxin C, Nikkomycin Z

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
13 700,00 CZK
10 275,00 CZK

About This Item

Empirical Formula (Hill Notation):
C20H25N5O10
CAS Number:
Molecular Weight:
495.44
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
MDL number:

10 275,00 CZK

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Quality Segment

assay

≥90% (HPLC)

form

powder

solubility

H2O: soluble 5 mg/mL

antibiotic activity spectrum

fungi

mode of action

cell wall synthesis | interferes, enzyme | inhibits

storage temp.

2-8°C

SMILES string

C[C@@H]([C@H](N)C(=O)N[C@H]([C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O)C(O)=O)[C@H](O)c3ccc(O)cn3

InChI

1S/C20H25N5O10/c1-7(13(28)9-3-2-8(26)6-22-9)11(21)17(31)24-12(19(32)33)16-14(29)15(30)18(35-16)25-5-4-10(27)23-20(25)34/h2-7,11-16,18,26,28-30H,21H2,1H3,(H,24,31)(H,32,33)(H,23,27,34)/t7-,11-,12+,13-,14-,15+,16+,18+/m0/s1

InChI key

WWJFFVUVFNBJTN-JKEIIPFCSA-N

General description

Chemical structure: peptidyl nucleoside

Application

Nikkomycin Z is used as a selective competitive inhibitor of chitin synthetase 3 in studies on fungal cell wall development. It is a potential treatment for human Encephalitozoon hellem, a microsporidian species and is used to study the changes of chitin and β--glucan under Nikkomycin Z exposure.

Biochem/physiol Actions

Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

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This Item
S8559H7772T8902
description

≥90% (HPLC)

description

95% (HPLC), powder

description

lyophilized powder

description

≥90% (HPLC)

mode of action

cell wall synthesis | interferes, enzyme | inhibits

mode of action

enzyme | inhibits, DNA synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

antibiotic activity spectrum

fungi

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

viruses

antibiotic activity spectrum

Gram-positive bacteria, Gram-negative bacteria, parasites

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

lyophilized powder

form

-

assay

≥90% (HPLC)

assay

95% (HPLC)

assay

-

assay

≥90% (HPLC)

solubility

H2O: soluble 5 mg/mL

solubility

H2O: soluble, H2O: complete 20 mg/ml, clear, colorless to light yellow

solubility

H2O: 50 mg/mL

solubility

acetic acid: soluble 25 mg/mL, clear to hazy, yellow to brownish-yellow


Storage Class

11 - Combustible Solids

WGK

WGK 3

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves



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