The product N7143 is intended for Research Use Only and does not have approvals from any agency for i.p. injections. Nigericin is soluble in DMSO up to 50 mg/mL and in ethanol up to 20 mg/mL, with stock solutions able to be stored for up to 3 months at -20 °C.
N7143
Nigericin sodium salt
From Streptomyces hygroscopicus, ≥98% (TLC), Ionophore, powder
Synonym(s):
Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 5 590,00 CZK |
10 mg | Please contact Customer Service for Availability | 5 930,00 CZK |
50 mg | Please contact Customer Service for Availability | 20 800,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C40H67NaO11
CAS Number:
Molecular Weight:
746.94
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
3892398
Assay:
≥98% (TLC)
Form:
powder
Product Name
Nigericin sodium salt, ≥98% (TLC)
biological source
Streptomyces hygroscopicus
Quality Segment
assay
≥98% (TLC)
form
powder
antibiotic activity spectrum
Gram-positive bacteria
mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
[Na+].[H][C@@]1(CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C([O-])=O)C[C@]2([H])C[C@@H](OC)[C@@H](C)[C@]3(O2)O[C@@](C)(C[C@H]3C)[C@@]4([H])CC[C@](C)(O4)[C@]5([H])O[C@]([H])(C[C@@H]5C)[C@@]6([H])O[C@@](O)(CO)[C@H](C)C[C@@H]6C
InChI
1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+;/m0./s1
InChI key
MOYOTUKECQMGHE-PDEFJWSRSA-M
General description
Nigericin, a polyether ionophore, serves as a probe of ion transport across mitochondrial membranes. It catalyzes the overall electroneutral exchange of K+ for H+(1) and acts as a potassium efflux activator. It may enhance bactericidal action via inflammasome-independent mechanisms specific to NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3).[1] Nigericin is a linear molecule with rings of heterocyclic oxygen together with a hydroxyl group. In the membrane, the molecule cyclizes to form a structure like valinomycin. Nigericin forms a neutral complex while losing a proton when it binds a cation which can diffuse across the membrane as a mobile carrier. Nigericin in protonated noncomplexed form is also considered mobile.
Chemical structure: polyether
Application
Biochem/physiol Actions
Polyether ionophore that disrupts membrane potential and stimulates ATPase activity in mitochondria.
Polyether ionophore that disrupts membrane potential and stimulates ATPase activity in mitochondria. Ion selectivity is K+> Rb+≥ Cs+>> Na+.
Other Notes
As ion-selective electrode - an efficient K+-carrier.
1 of 1
This Item | |||
|---|---|---|---|
| form powder | form - | form solution | form - |
| assay ≥98% (TLC) | assay ≥98% (HPLC) | assay - | assay ≥98% (HPLC) |
| Quality Level 300 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| biological source Streptomyces hygroscopicus | biological source Streptomyces albus | biological source Streptomyces hygroscopicus | biological source Streptomyces albus |
| mode of action cell membrane | interferes | mode of action cell membrane | interferes | mode of action cell membrane | interferes | mode of action cell membrane | interferes |
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Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
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Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Has nigericin been tested or approved for intraperitoneal (i.p.) injection in mice?also advice on the safety of nigericin injection into mice and recommended solvents for its use.
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