N6413

Anti-NR4A2 (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-HZF-3, Anti-NOT, Anti-NURR1, Anti-RNR1, Anti-TINUR
• NACRES: NA.41
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IF, WB
• Citations: 14

Properties

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~70 kDa
• species reactivity: human, mouse, rat
• concentration: ~1.5 mg/mL
• technique(s): indirect immunofluorescence: 4-8 μg/mL using 3T3 cells, western blot: 1-2 μg/mL using HEK-293T cell lysate expressing human NR4A2
• UniProt accession no.: P43354
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... NR4A2(4929) ; mouse ... Nr4a2(18227) ; rat ... Nr4a2(54278)

Description

General description

NR4A2 (N-terminal) encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, includ

Nuclear receptor subfamily 4 group A member 2 (NR4A2) is part of transcriptional regulator subfamily, under the family of nuclear hormone receptors. It is a transcription factor expressed in the brain and T-cells.

Application

Anti-NR4A2 (N-terminal) antibody has been used in

• immunoblotting
• immunofluorescence
• western blotting

Biochem/physiol Actions

NR4A2 binds the NGFI-B (nerve growth factor-induced clone B) response element (NBRE) sequence (AAAGGTCA) as monomer. NR4A2 is induced by multiple extracellular signals, including fatty acids, stress, growth factors and neurotransmitters in a cell type specific manner. Hepatic expression of NR4A2 is induced by cAMP in response to glucagon and fasting. NR4A2 is essential for the differentiation of nigral dopaminergic neurons. NR4A2 mutations have been associated with disorders related to dopaminergic dysfunction, including Parkinson′s disease, schizophrenia.

Nuclear receptor subfamily 4 group A member 2 (NR4A2) acts as an activator of tyrosine hydroxylase. It is crucial for the process of DNA repair by melanocortin-1 receptor.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)