N3290

NKH 477

≥98% (HPLC), powder, adenylyl cyclase activator

• Synonym(s): 6-[3-(dimethylamino)propionyl]-forskolin, Colforsin dapropate hydrochloride, N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester b-Alanine hydrochloride
• Empirical Formula (Hill Notation): C₂₇H₄₃NO₈·HCl
• CAS Number: 138605-00-2
• Molecular Weight: 546.09
• UNSPSC Code: 12352200
• PubChem Substance ID: 329818606
• NACRES: NA.77
• MDL number: MFCD00236421
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: NKH 477, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 3 mg/mL, clear to slightly hazy (warmed)
• storage temp.: 2-8°C
• SMILES string: Cl.CN(C)CCC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@H]13)C=C
• InChI: 1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
• InChI key: VIRRLEDAYYYTOD-YHEOSNBFSA-N

Description

Biochem/physiol Actions

NKH 477 is a potent, orally active adenylyl cyclase activator.

NKH 477 is a potent, orally active adenylyl cyclase activator. It is a water soluble derivative of forskolin, and dose dependentyl increases cAMP and blocks potassium-induced contraction concetrations in smooth muscle strips (IC50 = 80 nM). NKH 477 causes relaxation of histamine treated guinea pig smooth muscle (IC50 = 32 nM).

Features and Benefits

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Preparation Note

A clear to slightly hazy solution is possible.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Codes: H300
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable