Skip to Content
Merck

Key Documents

View All Documentation

Skip To

N1413

NSCI

≥97% (HPLC), solid

Synonym(s):

1-(4-Methoxybenzyl)-5-[2-(pyridin-3-yl-oxymethyl)pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
5 100,00 CZK
4 335,00 CZK

About This Item

Empirical Formula (Hill Notation):
C26H25N3O6S
CAS Number:
872254-32-5
Molecular Weight:
507.56
UNSPSC Code:
12352200
PubChem Substance ID:
24897488
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
solid

4 335,00 CZK

List Price5 100,00 CZKSave 15%
Web-Only Promotion
Please contact Customer Service for Availability
​
Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

assay

≥97% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL, H2O: insoluble

storage temp.

−20°C

SMILES string

COc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N4CCC[C@H]4COc5cccnc5)cc1

InChI

1S/C26H25N3O6S/c1-34-20-8-6-18(7-9-20)16-28-24-11-10-22(14-23(24)25(30)26(28)31)36(32,33)29-13-3-4-19(29)17-35-21-5-2-12-27-15-21/h2,5-12,14-15,19H,3-4,13,16-17H2,1H3/t19-/m0/s1

InChI key

XDHJBIYJRNFDKS-IBGZPJMESA-N

Gene Information

human ... CASP1(834), CASP3(836), CASP6(839), CASP7(840), SUMO1(7341)

Application

NSCI has been used as an apoptosis inhibitor to study its effects on caspase 9 activity in cultured tick cells.[1] It has also been used as an apoptosis inhibitor in terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay to study anti-CD3-induced apoptosis in the cluster of differentiation 4 (CD4+) and cluster of differentiation 8 (CD8+) T cells from pleural effusions, mononuclear cells (PEMCs).[2]

Biochem/physiol Actions

1-(4-Methoxybenzyl)-5-[2-(pyridin-3-yl-oxymethyl)pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione (NSCI) is a nonpeptide caspase 3 selective inhibitor.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
G1918S3442V4515
NSCI ≥97% (HPLC), solid

Sigma-Aldrich

N1413

NSCI

Gö 6983 ≥97%

Sigma-Aldrich

G1918

Gö 6983

SB 216763 >98% (HPLC)

Sigma-Aldrich

S3442

SB 216763

VU0238429 solubility: ≥20 mg/mL in DMSO

Sigma-Aldrich

V4515

VU0238429

form

solid

form

powder

form

-

form

powder

assay

≥97% (HPLC)

assay

≥97%

assay

>98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: soluble 20 mg/mL, H2O: insoluble

solubility

DMSO: ≥20 mg/mL

Gene Information

human ... CASP1(834), CASP3(836), CASP6(839), CASP7(840), SUMO1(7341)

Gene Information

-

Gene Information

human ... GSK3A(2931), GSK3B(2932)

Gene Information

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Reviews

No rating value

Active Filters