N0665

NDSB 211

≥98% (TLC)

• Synonym(s): 3-[Dimethyl-(2-hydroxyethyl)ammonio]-1-propanesulfonate, Dimethyl(2-hydroxyethyl)(3-sulfopropyl)ammonium hydroxide inner salt, Dimethyl-2-hydroxyethylammoniumpropane sulfonate
• Empirical Formula (Hill Notation): C₇H₁₇NO₄S
• CAS Number: 38880-58-9
• Molecular Weight: 211.28
• NACRES: NA.25
• PubChem Substance ID: 329818450
• UNSPSC Code: 12161900
• EC Number: 254-176-0
• MDL number: MFCD01320397

Properties

• description: zwitterionic
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: solid
• mol wt: 211.28 g/mol
• technique(s): DNA extraction: suitable
• color: white
• solubility: methanol: 5 mg/mL, clear, colorless
• SMILES string: OCC[N+](C)(C)CCCS([O-])(=O)=O
• InChI: 1S/C7H17NO4S/c1-8(2,5-6-9)4-3-7-13(10,11)12/h9H,3-7H2,1-2H3
• InChI key: CNXPCGBLGHKAIL-UHFFFAOYSA-N

Description

General description

Dimethyl-2-hydroxyethylammoniumpropane sulfonate, or NDSB 211, is a nondetergent-sulfobetain. It is zwitterionic over a wide pH range, easily removed by dialysis and shows no significant absorption in the near UV range.

Application

NDSB 211 has been used in a study to assess halophilic protein stabilization by the mild solubilizing agents nondetergent sulfobetaines. It has also been used in a study to investigate an alternative strategy for crystallizing macromolecules.

Non-detergent sulfobetaine is a compound used for non-denaturing protien purification. Increases the extraction yield of membrane, nuclear and cytoskeletal associated proteins. Zwitterionic over a wide pH range, easily removed by dialysis and no significant absorption in the near UV range. Specific applications include microsomal protein extraction, nuclear protein recovery, precipitation reduction in IEF, and membrane-bound protease purification.

Other Notes

This product is non-micelle forming.

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Codes: H314
• Precautionary Statements: P280 - P305 + P351 + P338 - P310
• Hazard Classifications: Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable