MAK154
Fluorometric Sphingomyelin Assay Kit
sufficient for 100 fluorometric tests
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| Size/SKU | Availability | Price |
|---|---|---|
1 kit | Please contact Customer Service for Availability | 12 400,00 CZK 10 168,00 CZK |
About This Item
NACRES:
NA.84
UNSPSC Code:
12161503
10 168,00 CZK
List Price12 400,00 CZKSave 18%Please contact Customer Service for Availability
usage
sufficient for 100 fluorometric tests
detection method
fluorometric
relevant disease(s)
cancer
storage temp.
−20°C
General description
Sphinogmyelin, a sphingolipid consisting of a phospholipid (typically phosphocholine) attached to a ceramide moiety, is a major component of cellular membranes. Sphingomylein is enriched in the exoplasmic leaflet of the cell membrane. Within the cell membrane, sphingomyelin interacts with cholesterol to form lipid rafts. The metabolism of sphingomyelin contributes to cellular signaling via the release of ceramide, a second messenger that participates in multiple cellular signaling pathways. Sphingomyelin accumulates in Niemann-Pick disease due to deficiencies in sphingomyelinase activity.
Application
This kit is suitable for the detection of sphingomyelin in a variety of samples such as blood and cell extracts.
Biochem/physiol Actions
Sphingomyelin is determined by a coupled enzyme assay, in which the hydrolysis of sphingomyelin by sphingomyelinase produces phosphocholine, which results in a fluorescent product (λex =540/λem = 590 nm) proportional to the Sphingomyelin present.
1 of 1
This Item | |||
|---|---|---|---|
| description sufficient for 100 fluorometric tests | description sufficient for 200 colorimetric tests | description from chicken egg yolk, ≥98.0% (TLC) | description sufficient for 100 colorimetric or fluorometric tests |
| usage sufficient for 100 fluorometric tests | usage sufficient for 200 colorimetric tests | usage - | usage - |
| detection method fluorometric | detection method colorimetric | detection method - | detection method colorimetric, fluorometric |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| relevant disease(s) cancer | relevant disease(s) rheumatological diseases; cancer | relevant disease(s) - | relevant disease(s) obesity; cardiovascular diseases; cancer |
Signal Word
Danger
Storage Class
10 - Combustible liquids
WGK
WGK 3
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - ED ENV 1 - Eye Dam. 1 - Resp. Sens. 1
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