M7320

N-Methylhistaprodifen dioxalate salt

≥98% (HPLC), solid

• Synonym(s): N-Methyl-2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]-ethanamine dioxalate salt
• Empirical Formula (Hill Notation): C₂₁H₂₅N₃ · 2 C₂H₂O₄
• CAS Number: 270079-48-6
• Molecular Weight: 499.51
• UNSPSC Code: 12352200
• MDL number: MFCD09752603

Properties

• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: ≥10 mg/mL, H₂O: insoluble <2 mg/mL
• storage temp.: 2-8°C
• SMILES string: OC(=O)C(O)=O.OC(=O)C(O)=O.CNCCc1c[nH]c(CCC(c2ccccc2)c3ccccc3)n1

Description

Biochem/physiol Actions

N-Methylhistaprodifen is a H1 histamine receptor agonist.

N-Methylhistaprodifen is more potent than histamine by a factor of 3.5 on guinea pig ileum; more potent than histamine by a factor of 4.3 on guinea pig arterial H₁-receptor-mediated vasoconstriction; most potent H₁-receptor agonist on the guinea pig ileum out of 17 agonists tested. pEC₅₀ = 7.24 in contraction of guinea pig ileal whole segments; pEC₅₀ = 6.31 in contraction of guinea pig aortic segments. N-methylhistaprodifen does not stimulate H₂ and H₃ histamine receptors; potential use in the study of H₁-receptor-mediated physiological and pathophysiological functions.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves