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Merck

M7068

MPP dihydrochloride hydrate

≥97% (HPLC), powder, estrogen receptor α agonist

Synonym(s):

1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride hydrate, Methyl-piperidino-pyrazole hydrate

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10 MG

CZK 5,170.00

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CZK 9,265.00

CZK 5,170.00

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About This Item

Empirical Formula (Hill Notation):
C29H31N3O3 · 2 HCl · xH2O
CAS Number:
911295-24-4
Molecular Weight:
542.50 (anhydrous basis)
UNSPSC Code:
51111800
PubChem Substance ID:
24724540
NACRES:
NA.77
MDL number:
MFCD06411603
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

Key Documents

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Product Name

MPP dihydrochloride hydrate, ≥97% (HPLC), white, powder

Quality Level

100

assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: soluble ≥20 mg/mL

SMILES string

Cl.Cl.Cc1c(nn(-c2ccc(O)cc2)c1-c3ccc(OCCN4CCCCC4)cc3)-c5ccc(O)cc5

InChI

1S/C29H31N3O3.2ClH/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31;;/h5-16,33-34H,2-4,17-20H2,1H3;2*1H

InChI key

FWDNPWVVRVSJQH-UHFFFAOYSA-N

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PZ0159G5793PZ0136
MPP dihydrochloride hydrate ≥97% (HPLC), white, powder

Sigma-Aldrich

M7068

MPP dihydrochloride hydrate

MCOPPB trihydrochloride hydrate >98% (HPLC)

Sigma-Aldrich

PZ0159

MCOPPB trihydrochloride hydrate

GR 127935 hydrochloride hydrate >98% (HPLC), powder

Sigma-Aldrich

G5793

GR 127935 hydrochloride hydrate

CP-100263 dihydrochloride hydrate ≥97% (HPLC)

Sigma-Aldrich

PZ0136

CP-100263 dihydrochloride hydrate

assay

≥97% (HPLC)

assay

>98% (HPLC)

assay

>98% (HPLC)

assay

≥97% (HPLC)

form

powder

form

powder

form

powder

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

-

solubility

DMSO: soluble ≥20 mg/mL

solubility

H2O: ≥13 mg/mL

solubility

DMSO: 10 mg/mL, clear

solubility

H2O: ≥5 mg/mL

color

white

color

white to tan

color

white to beige

color

white to off-white

General description

Methyl-piperidino-pyrazole hydrate (MPP) is prepared from a methyl-pyrazole-triol (MPT), a pyrazole triol.[1]

Application

MPP dihydrochloride hydrate has been used as an estrogen receptor α antagonist:
  • in human breast cancer MCF-7 cells[2]
  • to pre-treat endometrial ex vivo organ cultures (EVOCs)[3]
  • to treat pituitary glands to monitor luteinizing hormone secretion[4]

Biochem/physiol Actions

MPP dihydrochloride is a specific estrogen receptor α antagonist.
Methyl-piperidino-pyrazole hydrate (MPP) is an agonist for estrogen receptor α and lacks any ligand functionality with estrogen receptor (ER)β.[1] It promotes silibinin induced apoptosis in human breast cancer MCF-7 cells.[2]
Specific estrogen receptor α antagonist.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000485596
0000485596
0000425768
0000425769
0000425769

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Nan Zheng et al.
Journal of pharmacological sciences, 128(3), 97-107 (2015-06-29)
The estrogen receptor alpha (ERα) has been proven to be one of the most important therapeutic targets in breast cancer over the last 30 years. Previous studies pointed out that a natural flavonoid, silibinin, induced apoptosis in human breast cancer
Fu Guangtao et al.
Frontiers in pharmacology, 12, 746391-746391 (2021-11-23)
Periprosthetic osteolysis is one of the major long-term complications following total joint replacement. Its cause is widely accepted to be wear particle-induced activation of inflammatory macrophages. No effective strategy for the prevention and treatment of periprosthetic osteolysis is yet available.
Hai-Bing Zhou et al.
Bioorganic & medicinal chemistry letters, 19(1), 108-110 (2008-11-19)
Methyl-piperidino-pyrazole (MPP), an estrogen receptor alpha (ERalpha)-selective antagonist we developed, has a basic side chain (BSC) attached to an ERalpha-selective agonist ligand, methyl-pyrazole-triol (MPT) through an ether linkage. To remove the possibility that metabolic cleavage of the BSC in MPP
Julia Y H Liu et al.
General and comparative endocrinology, 272, 63-75 (2018-12-06)
Estrogen is well known to have a modulatory role on gastrointestinal tract, particularly through its interaction with nuclear estrogen receptors (ERs), alpha and beta (ERα/β). Recent functional studies also indicate that estrogen can activate a G-protein coupled estrogen receptor, GPR30
João P E Saut et al.
Reproduction (Cambridge, England), 148(6), 593-606 (2014-09-24)
The risk of bacterial infection of the endometrium causing uterine disease in cattle is increased in the progesterone-dominated luteal phase of the ovarian cycle, while oestrogens or oestrus are therapeutic or protective against disease. The first line of defence against
View All Related Papers

Global Trade Item Number

SKUGTIN
M7068-25MG04061833272930
M7068-10MG04061834061595

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