M6680

Se-(Methyl)selenocysteine hydrochloride

≥95% (TLC), apoptosis inducer

• Empirical Formula (Hill Notation): C₄H₉NO₂Se · HCl
• CAS Number: 863394-07-4
• Molecular Weight: 218.54
• UNSPSC Code: 12352209
• PubChem Substance ID: 24278564
• NACRES: NA.32
• MDL number: MFCD03412450

Properties

• Product Name: Se-(Methyl)selenocysteine hydrochloride, ≥95% (TLC)
• Quality Segment: 200
• assay: ≥95% (TLC)
• storage temp.: −20°C
• SMILES string: Cl.C[Se]C[C@H](N)C(O)=O
• InChI: 1S/C4H9NO2Se.ClH/c1-8-2-3(5)4(6)7;/h3H,2,5H2,1H3,(H,6,7);1H/t3-;/m0./s1
• InChI key: JMPVTFHGWJDSDV-DFWYDOINSA-N

Description

General description

Selenium (Se)-(Methyl) selenocysteine (MeSeCys) is a methylated product of selenocysteine, this reaction is catalyzed by selenocysteine methyltransferase (SMT) in Astragalus bisulcatus.

Application

Se-(Methyl) selenocysteine hydrochloride has been used as a standard in fluorescence-XANES (X-ray absorption near-edge spectroscopy) imaging.

Biochem/physiol Actions

Se-(Methyl)selenocysteine is a chemopreventive agent that blocks cell cycle progression and proliferation of premalignant mammary lesions and induces apoptosis of cancer cell lines in culture.

Selenium (Se)-(Methyl) selenocysteine functions as a potent chemotherapeutic agent for human breast cancer. Enhanced production of methlylselenol from L-Se-methylselenocysteine in vivo alters redox status of cells and oxidatively triggers cellular apoptosis. It is implicated in inhibition of mammary tumor formation in rats.

Safety Information

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• hcodes: H301 + H331,H373,H410
• pcodes: P260 - P264 - P273 - P301 + P310 - P304 + P340 + P311 - P314
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable