M5939
(R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide
>95% (HPLC)
Promotion Available
Synonym(s):
GM6001, Galardin, Ilomastat
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 16 600,00 CZK |
About This Item
Quality Segment
assay
>95% (HPLC)
form
solid
storage temp.
2-8°C
SMILES string
CNC([C@@H](NC([C@@H](C(C)C)CC(NC)=O)=O)CC1=CNC2=CC=CC=C21)=O
InChI
1S/C20H28N4O3/c1-12(2)15(10-18(25)21-3)19(26)24-17(20(27)22-4)9-13-11-23-16-8-6-5-7-14(13)16/h5-8,11-12,15,17,23H,9-10H2,1-4H3,(H,21,25)(H,22,27)(H,24,26)/t15-,17+/m1/s1
InChI key
PFBWZAGFLVKAGR-WBVHZDCISA-N
Application
- To study its effect on the profiling of active aggrecanases and their specific aggrecan degradation fragments.
- To study the involvement of autocrine EGF (epidermal growth factor) receptor activation in the regulation of the morphogenetic process, using human umbilical vein endothelial cells.
- To study the effect of GM6001 blockade on the expression of angiotensin II, the interstitial collagenases and soluble elastin fragments in explant culture supernatants.
Biochem/physiol Actions
1 of 1
This Item | |||
|---|---|---|---|
| description >95% (HPLC) | description GM 6001, CAS 142880-36-2, is a potent, cell-permeable, broad-spectrum inhibitor of matrix metalloproteinases. | description The IKK-2 Inhibitor IV, also referenced under CAS 507475-17-4, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. | description InSolution, ≥95%, broad-spectrum inhibitor of MMPs |
| assay >95% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (HPLC) |
| form solid | form solid | form solid | form liquid |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
![(R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide >95% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/381/824/43d65d68-be23-4584-80e5-31662c7f8f4a/640/43d65d68-be23-4584-80e5-31662c7f8f4a.png)
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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