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M3655

Sigma-Aldrich

D-Mannose 6-phosphate sodium salt

≥98% (HPLC)

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About This Item

Linear Formula:
C6H12O9PNa
CAS Number:
Molecular Weight:
282.12
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.25

biological source

synthetic (inorganic)

Assay

≥98% (HPLC)

form

powder

technique(s)

HPLC: suitable

impurities

<12% water (Karl Fischer)

color

white

solubility

water: 50 mg/mL, clear to cloudy, colorless

cation traces

Na: 7.3-9.0% (anhydrous)

storage temp.

2-8°C

SMILES string

[Na].OC(COP(O)(O)=O)C(O)C(O)C(O)C=O

InChI

1S/C6H13O9P.Na.H/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14;;/h1,3-6,8-11H,2H2,(H2,12,13,14);;

InChI key

RUFPTDNHMAGVMV-UHFFFAOYSA-N

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General description

Mannose is a monosaccharide.

Application

Mannose has been used in a study to assess in vivo targeting of alveolar macrophages. It has also been used in a study to investigate genetic engineering of the phosphocarrier protein NPr.

Biochem/physiol Actions

Mannose-6-Pis a molecule bound by lectin in the immune system. It is converted to fructose 6-phosphate by mannose phosphate isomerase and is a key targeting signal for acid hydrolase precursor proteins that are transported to lysosomes.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Yossef Lopez-de Los Santos et al.
The Journal of biological chemistry, 287(35), 29931-29939 (2012-07-07)
The Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system (PTS) in prokaryotes mediates the uptake and phosphorylation of its numerous substrates through a phosphoryl transfer chain where a phosphoryl transfer protein, HPr, transfers its phosphoryl group to any of several sugar-specific Enzyme IIA
Xuezheng Song et al.
Methods in molecular biology (Clifton, N.J.), 808, 137-148 (2011-11-08)
Glycan microarrays prepared by immobilization of amino-functionalized glycans on NHS-activated glass slides have been successfully used to study protein-glycan interactions. Fluorescently tagged glycans with an amino functional group can be prepared from natural glycans released from glycoproteins. These tagged glycans
C Henrique Serezani et al.
Journal of immunology (Baltimore, Md. : 1950), 189(2), 906-915 (2012-06-15)
Pattern recognition receptors for fungi include dectin-1 and mannose receptor, and these mediate phagocytosis, as well as production of cytokines, reactive oxygen species, and the lipid mediator leukotriene B(4) (LTB(4)). The influence of G protein-coupled receptor ligands such as LTB(4)
Changsuo Xia et al.
Orthopedics, 35(7), e1056-e1060 (2012-07-13)
The purpose of this study was to investigate the preventive effect of mannose-6-phosphate on flexor tendon adhesion formation. From a total of 84 adult New Zealand White rabbits, 36 were randomly divided into 2 groups, the normal saline group and
Petra Tiels et al.
Nature biotechnology, 30(12), 1225-1231 (2012-11-20)
Lysosomal storage diseases are treated with human lysosomal enzymes produced in mammalian cells. Such enzyme therapeutics contain relatively low levels of mannose-6-phosphate, which is required to target them to the lysosomes of patient cells. Here we describe a method for

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