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M2199

PMEG hydrate

≥98% (HPLC)

Synonym(s):

9-[2-(Phosphonomethoxy)ethyl]guanine hydrate

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About This Item

Empirical Formula (Hill Notation):
C8H12N5O5P · xH2O
CAS Number:
1255517-79-3
Molecular Weight:
289.19 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
329817932
UNSPSC Code:
12352202
MDL number:
MFCD19443863
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated
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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

O.NC1=Nc2c(ncn2CCOCP(O)(O)=O)C(=O)N1

InChI

1S/C8H12N5O5P.H2O/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-18-4-19(15,16)17;/h3H,1-2,4H2,(H2,15,16,17)(H3,9,11,12,14);1H2

InChI key

BDVQXHFCXJXVND-UHFFFAOYSA-N

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PMEG hydrate ≥98% (HPLC)

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Sigma-Aldrich

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Dimebon dihydrochloride hydrate ≥98% (HPLC)

Sigma-Aldrich

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KDOAM25 hydrochloride hydrate ≥98% (HPLC)

Sigma-Aldrich

SML2774

KDOAM25 hydrochloride hydrate

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: ≥5 mg/mL

solubility

DMSO: ≥45 mg/mL

solubility

H2O: ≥10 mg/mL

solubility

H2O: 2 mg/mL, clear

storage condition

desiccated

storage condition

desiccated

storage condition

-

storage condition

desiccated

Biochem/physiol Actions

The acyclic nucleotide 9-(2-phosphonylmethoxyethyl)guanine (PMEG) forms an active phosphorylated metabolite, PMEG diphosphate (PMEGpp), in cells and causes cytotoxicity in dividing cells due to potent inhibition of the nuclear DNA polymerases resulting in inhibition of DNA synthesis and/or DNA repair.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
020M4606V
020M4606

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HIV-1 infection is a complex, multi-step process involving not only viral, but also multiple cellular factors. To date, drug discovery methods have primarily focused on the inhibition of single viral proteins. We present an efficient and unbiased approach, compatible with

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