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M0639
6α-Methylprednisolone
synthetic, ≥98%, glucocorticoid, powder
Synonym(s):
11β,17α,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, Medrol, Medrone
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| Size/SKU | Availability | Price |
|---|---|---|
100 mg | Please contact Customer Service for Availability | 4 780,00 CZK |
250 mg | Please contact Customer Service for Availability | 11 200,00 CZK 9 520,00 CZK |
1 g | Please contact Customer Service for Availability | 23 300,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C22H30O5
CAS Number:
Molecular Weight:
374.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
201-476-4
MDL number:
Beilstein/REAXYS Number:
2340300
Assay:
≥98%
Form:
powder
Product Name
6α-Methylprednisolone, ≥98%
biological source
synthetic
Quality Segment
sterility
non-sterile
assay
≥98%
form
powder
solubility
chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow
application(s)
cell analysis
shipped in
ambient
storage temp.
room temp
SMILES string
[H][C@@]12C[C@H](C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
InChI
1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
InChI key
VHRSUDSXCMQTMA-PJHHCJLFSA-N
Gene Information
human ... NR3C1(2908)
rat ... Nr3c1(24413)
Application
6α-Methylprednisolone has been used:
- to stimulate RPMI 8226.1 cells in order to govern the expression of human interleukin-10 (IL-10) gene
- to induce depletion of CD14+ CD16+ monocytes
- to study its effect on behavioral and sensory afferent hypersensitivity
Biochem/physiol Actions
Methylprednisolone is a glucocorticoid having anti-inflammatory and immunosuppressive actions. It is useful in treating skin diseases, allergies, multiple sclerosis, asthma, rheumatic disorders, chronic obstructive pulmonary disease, croup and cancer.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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This Item | |||
|---|---|---|---|
| description ≥98% | description United States Pharmacopeia (USP) Reference Standard | description European Pharmacopoeia (EP) Reference Standard | description Pharmaceutical Secondary Standard; Certified Reference Material |
| assay ≥98% | assay - | assay - | assay - |
| form powder | form - | form - | form - |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level 300 |
| storage temp. room temp | storage temp. - | storage temp. - | storage temp. 2-30°C |
| solubility chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow | solubility - | solubility - | solubility - |
| shipped in ambient | shipped in - | shipped in wet ice | shipped in - |
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Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Repr. 1B - STOT RE 2
Target Organs
Adrenal gland,Immune system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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What solvents can be used for Methylprednisolone?
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Sigma tests the solublity of Methylprednisolone at 50 mg/ml in chloroform:methanol (1:1) yielding a clear, colorless to faint yellow solution. This product is practically insoluble in water, soluble 1 in 100 of dehydrated ethanol (10 mg/ml), slightly soluble in chloroform and ether; sparingly soluble in dioxan and methanol. It has been reported that this product is soluble in DMSO at a concentration of 100 mM. An NMR has been run using DMSO-d6 suggesting this product is soluble at 5-10 mg/ml in DMSO.
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