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Yes, this compound is generally soluble in water due to polar/ionizable peptide groups and the acetate salt form. This product is tested for solubility at 5 mg/mL. However, other sources indicate that the material is soluble up to 100 mg/mL in water with heat or sonication. This information has not been validated.
L9133
Leucine Enkephalin acetate salt hydrate
≥95% (HPLC), μ- and δ-opioid receptor agonist
Synonym(s):
Leucine Enkephalin
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| Size/SKU | Availability | Price |
|---|---|---|
10 mg | Please contact Customer Service for Availability | CZK 2,830.00 |
25 mg | Please contact Customer Service for Availability | CZK 3,860.00 |
About This Item
Empirical Formula (Hill Notation):
C28H37N5O7 · xC2H4O2 · yH2O
Molecular Weight:
555.62 (anhydrous free base basis)
UNSPSC Code:
12352209
eCl@ss:
32160409
PubChem Substance ID:
NACRES:
NA.32
MDL number:
Product Name
Leucine Enkephalin acetate salt hydrate, ≥95% (HPLC)
Quality Segment
assay
≥95% (HPLC)
storage temp.
−20°C
SMILES string
O.CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O
InChI
1S/C28H37N5O7.C2H4O2.H2O/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19;1-2(3)4;/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40);1H3,(H,3,4);1H2/t21-,22-,23-;;/m0../s1
InChI key
QKDIOZBQOQJXFR-XQCXOTTHSA-N
Gene Information
human ... OPRD1(4985), OPRM1(4988)
mouse ... OPRD1(18386), OPRM1(18390)
rat ... OPRD1(24613), OPRM1(25601)
General description
Leucine Enkephalin is a pentapeptide and is a normal component of central and peripheral tissues.[1] Leucine Enkephalin has amino acid sequence Tyr-Gly-Gly-Phe-Leu and is distributed in the brains of many animals, including humans. It is an endogenous opioid neurotransmitter/neuromodulator localized in brain parallels and in δ receptors.
Application
Leucine Enkephalin acetate salt hydrate has been used in the calibration of the Q-Tof Micro hybrid, triple quadrupole-orthogonal acceleration time of flight (TOF) instrument in single-stage TOF mode. It has also been used to perform the calibration of mass spectrometry. It has also been used in liquid chromatography-mass spectrometry (LCMS)/MS for calibration of the system and for relative correction of the spectra.
Biochem/physiol Actions
Leucine Enkephalin (LEU-ENK) functions as agonists at both μ- and δ-opioid receptor sites.[1] It might also play a role as neurotransmitter agent at morphine-sensitive synapses.[1] Leucine Enkephalin is also associated with pain regulation.[2] LEU-ENK expressed in camel lacrimal nerve regulates lacrimal fluid and protein secretion. LEU-ENK is degraded during metabolism by several enzymes, including aminopeptidase-N (APN), neutral endopeptidase (NEP), dipeptidyl peptidase- 3 (DPP3), carboxy peptidase-A6 (CPA-6) and angiotensin converting enzyme (ACE), which are sometimes referred to as enkephalinases.
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This Item | |||
|---|---|---|---|
| assay ≥95% (HPLC) | assay ≥95.0% (HPLC) | assay ≥95% (HPLC) | assay ≥97% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Gene Information human ... OPRD1(4985), OPRM1(4988) | Gene Information human ... OPRD1(4985), OPRM1(4988) | Gene Information human ... OPRD1(4985) | Gene Information human ... OPRD1(4985), OPRK1(4986), OPRM1(4988) |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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hello, is Leucine Enkephalin acetate salt hydrate ready soluble in water? i Assume it is due to structural groups
1 answer-
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