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α-Lactalbumin from bovine milk

Name: α-Lactalbumin from bovine milk
Brand: SIGMA
Price: 4210 CZK

Type III, calcium depleted, ≥85% (PAGE), lyophilized powder

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Synonym(s):

Bos d 4, Lactose synthase B protein, alpha-lactalbumin

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Size/SKU	Availability	Price
100 mg	Please contact Customer Service for Availability	4 210,00 CZK
500 mg	Please contact Customer Service for Availability	12 600,00 CZK
1 g	Please contact Customer Service for Availability	21 600,00 CZK

About This Item

CAS Number:

9051-29-0

UNSPSC Code:

12352202

NACRES:

NA.61

MDL number:

MFCD00162025

Biological source:

bovine milk

Assay:

≥85% (PAGE)

Form:

lyophilized powder

Technique(s):

indirect ELISA: suitable

Impurities:

cation traces, tested

Concentration:

≥85 % protein

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Properties

biological source

bovine milk

Quality Segment

300

type

Type III

assay

≥85% (PAGE)

form

lyophilized powder

quality

calcium depleted

mol wt

14,178 Da by calculation

concentration

≥85 % protein

technique(s)

indirect ELISA: suitable

impurities

cation traces, tested

solubility

H₂O: soluble 10 mg/mL, clear to slightly hazy, colorless to faintly yellow

cation traces

Ca: ≤0.3 mol/mol

UniProt accession no.

P00711

storage temp.

−20°C

Gene Information

cow ... LALBA(281894)

Description

General description

may contain traces of (NH₄)₂SO₄ and sodium phosphateL6010

Application

α-Lactalbumin from bovine milk has been used:

in indirect enzyme-linked immunosorbent assay (ELISA) and competitive ELISA methods
in binding of Hsp90 and HSJ1b analysis
to inhibit the lysozyme CAP-RAST assay

Biochem/physiol Actions

α-Lactalbumin is the cheif protein in human milk. It consists of a single polypeptide chain with 8 cysteines which form disulfide bridges. α-Lactalbumin binds several metal ions, including calcium, which is thought to play a role in the regeneration of native α-lactalbumin from the reduced, denatured form. α-Lactalbumin also has a distinct zinc binding site that is thought to play a role in the binding of the lactose synthase complex.The mature protein consists of 123 amino acid residues (14 kD), and it has a three-dimensional structure with 1.7 Angstrom resolution, demonstrating four α-helices and a triple stranded antiparallel β-sheet.

Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase.

Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase. Site-directed mutagenesis of Asp⁸⁷ or Asp⁸⁸ to Ala completely abolishes the strong calcium binding affinity and reduces the stimulation of lactose synthase to <3.5% of the maximal rate.

Analysis Note

May contain traces of (NH₄)₂SO₄ and sodium phosphate.

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This Item	L5385	L4385	L9507
Sigma-Aldrich L6010 α-Lactalbumin from bovine milk	Sigma-Aldrich L5385 α-Lactalbumin from bovine milk	Sigma-Aldrich L4385 α-Lactalbumin from bovine milk	Sigma-Aldrich L9507 Lactoferrin from bovine milk
description Type III, calcium depleted, ≥85% (PAGE), lyophilized powder	description Type I, ≥85% (PAGE), lyophilized powder	description Marker for non-denaturing PAGE	description ≥85% (SDS-PAGE)
technique(s) indirect ELISA: suitable	technique(s) cell culture \| mammalian: suitable, electrophoresis: suitable	technique(s) microbiological culture: suitable	technique(s) fractionation: suitable
assay ≥85% (PAGE)	assay ≥85% (PAGE)	assay -	assay ≥85% (SDS-PAGE)
biological source bovine milk	biological source bovine milk	biological source bovine milk	biological source bovine milk
Quality Level 300	Quality Level 300	Quality Level 200	Quality Level 200
form lyophilized powder	form lyophilized powder	form lyophilized powder	form powder
Gene Information cow ... LALBA(281894)	Gene Information cow ... LALBA(281894)	Gene Information cow ... LALBA(281894)	Gene Information cow ... LTF(280846)

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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