L2506

β-Lactoglobulin from bovine milk

≥85% (PAGE), lyophilized powder

• Synonym(s): β-LG, Bos d 5, beta-LG
• CAS Number: 9045-23-2
• EC Number: 232-928-9
• MDL number: MFCD00130635
• UNSPSC Code: 12352202
• NACRES: NA.61

Properties

• biological source: bovine milk
• Assay: ≥85% (PAGE)
• form: lyophilized powder
• technique(s): titration: suitable
• UniProt accession no.: P02754
• storage temp.: 2-8°C
• Gene Information: bovine ... LGB(280838)

Description

General description

β-Lactoglobulin plays a key role in immune response and modulates IgM levels and cell proliferation. β-Lactoglobulin from bovine is a model system for protein folding studies and denaturation kinetics. Polymorphisms in the β-lactoglobulin modulates bovine milk production and composition.

A member of the lipocalin family, βLg is a small protein of 162 amino acids with a molecular mass of ∼18,400 Da,. It has an eight-stranded β-barrel (strands A-H) succeeded by a three-turn a-helix and a final β-strand (strand I) that forms part of the dimerization interface.

Milk from dairy cows contains the protein β-lactoglobulin (BLG). It naturally occurs in a number of genetic variants, and the most prevalent bovine variants are BLG A and BLG B.

Application

β-Lactoglobulin from bovine milk has been used:

• for the generation of calibration curve for protein solubility index
• in acid-base titration
• as a standard for surface hydrophobicity analysis

β-Lactoglobulin was used in a cytologic assay for diagnosis of food hypersensitivity in patients with irritable bowel syndrome.

Quality

Contains β-lactoglobulins A and B which can be isolated chromatographically.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves