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K3761

KT 5720

From microbial, ≥98% (HPLC), PKA inhibitor, powder

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Synonym(s):

(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester

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Size/SKUAvailabilityPrice
0.1 mg
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6 460,00 CZK

About This Item

Empirical Formula (Hill Notation):
C32H31N3O5
CAS Number:
Molecular Weight:
537.61
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:

6 460,00 CZK

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Product Name

KT 5720, ≥98% (HPLC), powder

biological source

microbial

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to faint yellow

solubility

methanol: 5 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

CCCCCCOC([C@@]1(O)C[C@@]2([H])N3C(C=CC=C4)=C4C5=C3C6=C(C(C=CC=C7)=C7N6[C@]1(C)O2)C8=C5C(NC8)=O)=O

InChI

1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32-/m0/s1

InChI key

ZHEHVZXPFVXKEY-IKZDWWSZSA-N

Application

KT 5720 has been used as a chemical inhibitor of cell signaling pathway. It has also been used as a protein kinase A (PKA) inhibitor to study its effect on the nuclear import of CRTC1 in α-MSH-activated B16-F0 cells and on COX-2 stimulation of tumor-associated Vascular endothelial growth factor (VEGF) expression.

Biochem/physiol Actions

Specific, cell-permeable inhibitor of protein kinase A (PKA). No significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (MLCK).

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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1 of 1

This Item
420323420320319856
description

≥98% (HPLC), powder

description

InSolution, ≥95%

description

A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a.

description

99 atom % D

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

99% (CP)

biological source

microbial

biological source

-

biological source

-

biological source

-

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

200

form

powder

form

liquid

form

solid

form

-

solubility

methanol: 5 mg/mL

solubility

DMSO: soluble

solubility

DMSO: 1 mg/mL

solubility

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

67-56-1

CAS No.


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