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JNJ7777120

Name: JNJ7777120
Brand: SIGMA
Price: 3731.5 CZK

≥98% (HPLC), histamine receptor antagonist, solid

Synonym(s):

1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methyl-piperazine

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Size/SKU	Availability	Price
5 mg	Please contact Customer Service for Availability	CZK 4,390.00 CZK 3,731.50
25 mg	Please contact Customer Service for Availability	CZK 16,600.00

About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₆N₃OCl

CAS Number:

459168-41-3

Molecular Weight:

277.75

UNSPSC Code:

12352200

PubChem Substance ID:

329815408

NACRES:

NA.77

MDL number:

MFCD04343337

Assay:

≥98% (HPLC)

Form:

solid

CZK 3,731.50

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Properties

Product Name

JNJ7777120, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: >20 mg/mL, H₂O: insoluble

originator

Johnson & Johnson

storage temp.

room temp

SMILES string

CN1CCN(CC1)C(=O)c2cc3cc(Cl)ccc3[nH]2

InChI

1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3

InChI key

HUQJRYMLJBBEDO-UHFFFAOYSA-N

Description

Application

JNJ7777120 has been used as a histamine-4 receptor antagonist:

to study its effects on the pro-inflammatory microglia in rats[1]
to study its effects on the Parkinson′s-like pathology in rat brain[2]
to study its effects on the histamine receptor interaction in periodontal ligament fibroblasts (PDLF)[3]

Biochem/physiol Actions

JNJ7777120 is a potent, selective non-imidazole H₄ histamine receptor antagonist.

JNJ7777120 may exhibit neuroprotective effects against ischemic brain damage.[4] It acts as an anti-inflammatory agent to treat inflammatory diseases. JNJ7777120 is observed to reduce colonic injury, cytokine production, and neutrophil infiltration.[5]

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Show Differences

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This Item	SML0857	Z4152	SML2940
Sigma-Aldrich J3770 JNJ7777120	Sigma-Aldrich SML0857 HQL 79	Sigma-Aldrich Z4152 Zafirlukast	Sigma-Aldrich SML2940 ML417
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form powder	form solid	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. room temp	storage temp. room temp	storage temp. room temp	storage temp. 2-8°C
solubility DMSO: >20 mg/mL, H₂O: insoluble	solubility DMSO: 2 mg/mL, clear (warmed)	solubility DMSO: ≥28 mg/mL	solubility DMSO: 2 mg/mL, clear
color white to off-white	color white to beige	color -	color white to beige

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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