I8907

Interferon β from rat

≥95%, recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture

• Synonym(s): IFN-β
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD04040885

Properties

• biological source: rat
• Quality Segment: 200
• recombinant: expressed in CHO cells
• assay: ≥95%
• form: lyophilized powder
• mol wt: ~20 kDa
• packaging: pkg of 1 vial
• concentration: ≥100000 units/mL
• technique(s): cell culture | mammalian: suitable
• UniProt accession no.: P70499
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: rat ... Ifnb1(24481)

Description

Biochem/physiol Actions

Interferon β belongs to the type 1 interferon family pf proteins. It is also needed for the inhibition of tumor cell growth via cell death, S-phase increase and mediating differentiation. It is also important for bone homeostasis.

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.

Physical form

Lyophilized from phosphate buffered saline (PBS) containing 125 mM trehalose.

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using rat epithelial-like (RATEC) cells with vesicular stomatitis virus (VSV). The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. Since there is no international rat interferon β standard, units are determined with respect to the NIH international standard reference for mouse interferon α/β.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)