I6659

Imperatorin

≥98% (HPLC), AChE inhibitor, powder

• Synonym(s): 8-Isopentenyloxypsoralene, 9-(3-Methylbut-2-enyloxy)-7H-furo[3,2-g]chromen-7-one, 9-[(3-Methyl-2-buten-1-yl)oxy]-7h-furo[3,2-g][1]benzopyran-7-one, Ammidin, Marmelide, Marmelosin, NSC 402949
• Empirical Formula (Hill Notation): C₁₆H₁₄O₄
• CAS Number: 482-44-0
• Molecular Weight: 270.28
• NACRES: NA.77
• PubChem Substance ID: 329815395
• UNSPSC Code: 12352200
• EC Number: 207-581-1
• MDL number: MFCD00016881
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Imperatorin, ≥98% (HPLC), powder
• assay: ≥98% (HPLC)
• form: powder
• color: off-white to light brown
• solubility: DMSO: ≥5 mg/mL
• storage temp.: 2-8°C
• SMILES string: C\C(C)=C\COc1c2OC(=O)C=Cc2cc3ccoc13
• InChI: 1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3
• InChI key: OLOOJGVNMBJLLR-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Imperatorin is an important bioactive furanocoumarin. It is used to treat neurodegenerative diseases. It possesses anticancer, antibacterial, anti-inflammatory and HIV replication-inhibiting activities. Imperatorin serves as an inhibitor of acetylcholinesterase (AChE) and may help in treating Alzheimer′s disease (AD) and Parkinson′s disease (PD).

Imperatorin is a modulator of p38, ERK pathway.

Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H317,H319,H335
• pcodes: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)