I5281

L-Isoleucine

• Synonym(s): (2S,3S)-2-Amino-3-methylpentanoic acid
• Linear Formula: C₂H₅CH(CH₃)CH(NH₂)CO₂H
• CAS Number: 73-32-5
• Molecular Weight: 131.17
• UNSPSC Code: 12352209
• NACRES: NA.26
• eCl@ss: 32160406
• EC Number: 200-798-2
• Beilstein/REAXYS Number: 1721792
• MDL number: MFCD00064222

Properties

• biological source: non-animal source
• Quality Segment: 400
• assay: ≥98.5%
• form: crystalline powder
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, residual solvents, tested
• mp: 288 °C (dec.) (lit.)
• solubility: 1 M HCl: 50 mg/mL
• application(s): downstream processes; pharma/biopharma processes; pharmaceutical (small molecule)
• foreign activity: cytotoxicity, tested
• SMILES string: CC[C@H](C)[C@H](N)C(O)=O
• InChI: 1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1
• InChI key: AGPKZVBTJJNPAG-WHFBIAKZSA-N

Description

General description

Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.

Application

L-Isoleucine is an essential amino acid. It can be biosynthesized from threonine or through fermentation of carbohydrates. The amino acid L-isoleucine is an isomer of L-Leucine, differing in the position of the side chain. It is also considered to be a branched chain amino acid, along with L-Leucine and L-Valine, which are sources of fuel and/or transport during cell development. It is used as a cell culture media component in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)