The solubility of this product has not been tested in-house. This product is Insulin-FITC supplied as a lyophilized powder containing sodium phosphate buffer salts and is expected to be soluble in water. Based on quality control testing, a similar product is soluble in water at a concentration of 2.5 mg/ml. Insulin is generally dissolved in mildly acidic solutions.
I3661
Insulin-FITC labeled human
recombinant, expressed in yeast, lyophilized powder
Synonym(s):
FITC Insulin, Labeled Human Insulin
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | CZK 14,000.00 |
About This Item
UNSPSC Code:
12352204
EC Number:
234-279-7
NACRES:
NA.83
Form:
lyophilized powder, solid
Recombinant:
expressed in yeast
recombinant
expressed in yeast
Quality Segment
form
lyophilized powder, solid
composition
Insulin, ≥75% biuret
extent of labeling
≥1 mol FITC per mol insulin
shipped in
dry ice
storage temp.
−20°C
General description
Insulin is a polypeptide hormone mainly secreted from pancreas when glucose level changes in the plasma. It is an anabolic hormone and enhances the generation of storage substances, for instance glycogen, fat and protein. It also induces glucose uptake by peripheral tissues, thereby controlling glucose levels in the plasma. Its main sites of action are liver, adipose tissue and muscle.
Application
Insulin-FITC labeled human has been used in primary endothelial cells from human adipose tissue microvasculature (HAMEC) to study insulin transcytosis.[1]
Physical form
Lyophilized powder containing sodium phosphate buffer salts
1 of 1
This Item | |||
|---|---|---|---|
| recombinant expressed in yeast | recombinant - | recombinant expressed in yeast (proprietary host) | recombinant expressed in yeast |
| form lyophilized powder, solid | form lyophilized (clear, colorless solution after reconstitution) | form powder | form lyophilized powder |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
| shipped in dry ice | shipped in - | shipped in ambient | shipped in ambient |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level 200 |
| extent of labeling ≥1 mol FITC per mol insulin | extent of labeling - | extent of labeling - | extent of labeling - |
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
wgk
WGK 3
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What is the solubility of this FITC insulin and what solvent should be used?
1 answer-
Helpful?
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How is the Insulin conjugated?
1 answer-
Regarding the location of the FITC label and any effects on activity, there is no specific description available on where the FITC label is positioned on FITC-insulin. However, in practice, there are only three potential sites where the FITC can derivatize the insulin. These locations include both of the N-terminal residues, off the free amine, and the Lysine at the 3rd position near the C-terminus of the B-chain.
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