I0911

IRR (945-end), active, GST tagged human

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(s): INSRR
• NACRES: NA.32
• UNSPSC Code: 12352204
• Specific activity: 94-128 nmol/min·mg
• Assay: ≥70% (SDS-PAGE)
• Recombinant: expressed in baculovirus infected Sf9 cells

Properties

• recombinant: expressed in baculovirus infected Sf9 cells
• Quality Segment: 200
• product line: PRECISIO^® Kinase
• assay: ≥70% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• specific activity: 94-128 nmol/min·mg
• mol wt: ~65 kDa
• UniProt accession no.: P14616
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... INSRR(3645)

Description

General description

IRR (insulin receptor-related receptor) belongs to the insulin receptor (IR) family. It is expressed in neuronal tissues, kidney, pancreas and stomach.[1][2]

Biochem/physiol Actions

IRR or insulin receptor-related receptor is a tyrosine protein kinase. IRR is an extracellular pH sensor. The IRR mRNA is present in neuroblastomas and may be associated with tumor genesis.[1][2]

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable