H9291
Hemopexin from human plasma
≥95% (SDS-PAGE), lyophilized powder
Synonym(s):
HPX, HX, Hpxn, beta-1B-glycoprotein
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| Size/SKU | Availability | Price |
|---|---|---|
500 μg | Please contact Customer Service for Availability | CZK 10,100.00 |
About This Item
Form:
lyophilized powder
Assay:
≥95% (SDS-PAGE)
Biological source:
human plasma
Mol wt:
~57 kDa
General description
Hemopexin (HPX) is produced by cells of the central nervous system. It is a 60 kDa serum glycoprotein.
Application
Hemopexin from human plasma has been used S. aureus surface colonization assay. It has also been used to stimulate mixed lymphocyte cells to determine the biomarkers in acute rejection.[1]
Biochem/physiol Actions
Hemopexin is an acute-phase protein that plays a major protective role against oxidative stress through its heme-scavenging activities. Hemopexin binds heme with high affinity and is critical for recycling the iron bound to heme molecules and for protecting against heme-induced cellular damage. Free heme, when released or lost from proteins like hemoglobin, can catalyze the formation of reactive oxygen species. Heme is lipophilic and interchelates into lipid membranes and participate in the formation of highly-toxic hydroxyl radicals. Hemopexin may also protect against the heme-mediated oxidation of LDL cholesterol.
Hemopexin may also serve an anti-inflammatory role via the negative regulation of IL-6 and TNF-α secretion by activated macrophages.
Hemopexin may also serve an anti-inflammatory role via the negative regulation of IL-6 and TNF-α secretion by activated macrophages.
Physical form
Lyophilized powder containing sodium phosphate, NaCl, and KCl, pH 7.4
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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This Item | |||
|---|---|---|---|
| assay ≥95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) | assay >90% (SDS-PAGE) |
| biological source human plasma | biological source human plasma | biological source human plasma | biological source human plasma |
| technique(s) microbiological culture: suitable | technique(s) - | technique(s) immunoelectrophoresis: suitable, immunoprecipitation (IP): suitable | technique(s) cell culture | mammalian: suitable |
| form lyophilized powder | form lyophilized | form lyophilized powder | form lyophilized powder |
| mol wt ~57 kDa | mol wt monomer 200 kDa (Hp 2-1), monomer 400 kDa (Hp 2-2), monomer 86 kDa (Hp 1-1) | mol wt - | mol wt 70 kDa |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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