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H5659

L-Histidine monohydrochloride monohydrate

98.5-101.0%, suitable for cell culture, BioXtra, non-animal source

Synonym(s):

L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride

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Size/SKUAvailabilityPrice
25 g
Please contact Customer Service for Availability
CZK 1,390.00
100 g
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CZK 3,570.00
1 kg
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CZK 21,900.00

About This Item

Empirical Formula (Hill Notation):
C6H9N3O2 · HCl · H2O
CAS Number:
Molecular Weight:
209.63
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26
Beilstein/REAXYS Number:
4168261
MDL number:

CZK 1,390.00


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Product Name

L-Histidine monohydrochloride monohydrate, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%

biological source

non-animal source

Quality Segment

agency

meets EP testing specifications

product line

BioXtra

assay

98.5-101.0%

form

crystalline powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

254 °C (dec.) (lit.)

solubility

H2O: 100 mg/mL

SMILES string

O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1

InChI key

CMXXUDSWGMGYLZ-XRIGFGBMSA-N

Application

L-Histidine monohydrochloride, non-animal, is used in cell culture media formulations used in biomanufacturing. The use of non-animal-sourced L-Histidine and other components avoids the risk of contaminating bioproducts with adventitious viruses.
L-Histidine monohydrochloride monohydrate has been used in bee cell culture medium.

Biochem/physiol Actions

L-Histidine is involved in the one-carbon unit metabolism. It is associated with protein methylation. L-Histidine is a part of hemoglobin structure and function. L-Histidine is a component of dipeptides with antioxidative property. Histidine serves as a precursor for the formation of histamine, which is associated with allergic responses. Urocanic acid, an immune response modulator in skin is also biosynthesised from histidine.

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This Item
1.043501.04354H8125
form

crystalline powder

form

crystalline powder

form

solid

form

-

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

-

assay

98.5-101.0%

assay

-

assay

98.5-101.0% (alkalimetric), 99.0-101.0% (perchloric acid titration)

assay

≥98% (HPLC)

product line

BioXtra

product line

-

product line

EMPROVE® EXPERT

product line

-

mp

254 °C (dec.) (lit.)

mp

254 °C (dec.) (lit.)

mp

254 °C (dec.) (lit.)

mp

254 °C (dec.) (lit.)

solubility

H2O: 100 mg/mL

solubility

149.55 g/L

solubility

149.55 g/L

solubility

H2O: 50 mg/mL, clear, colorless to very faintly yellow


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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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