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H0878

Heparin lithium salt from porcine intestinal mucosa

≥150 USP units/mg

Synonym(s):

Lithium acid heparin, Lithium heparinate

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Size/SKUAvailabilityPrice
100000 units
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CZK 3,420.00
1000000 units
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CZK 28,700.00

About This Item

CAS Number:
9045-22-1
UNSPSC Code:
12352201
NACRES:
NA.25
MDL number:
MFCD00131308

CZK 3,420.00

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biological source

Porcine intestinal mucosa

Quality Segment

200

form

powder

specific activity

≥150 USP units/mg

color

off-white

solubility

water: 40 mg/mL, clear, colorless to faint yellow or tan

cation traces

Li: 3-4%

application(s)

advanced drug delivery
diagnostic assay manufacturing
life science and biopharma
plasma purification
sample preparation

storage temp.

room temp

SMILES string

[S](=O)(=O)(NC1C(OC(C(C1O)OC2OC(C(C(C2O[S](=O)(=O)O)O)OC)C(=O)O)CO[S](=O)(=O)O)OC)O

InChI

1S/C14H25NO20S3/c1-29-9-7(17)10(35-38(26,27)28)14(34-11(9)12(18)19)33-8-4(3-31-37(23,24)25)32-13(30-2)5(6(8)16)15-36(20,21)22/h4-11,13-17H,3H2,1-2H3,(H,18,19)(H,20,21,22)(H,23,24,25)(H,26,27,28)

InChI key

HXSDFQWQRCUQHF-UHFFFAOYSA-N

General description

Heparin lithium is a highly sulfated polysaccharide that belongs to the family of glycosaminoglycans with remarkable significance in the areas of cell culture, cancer biology, biochemical, and drug discovery research. Due to its interactions with proteins and cells, it is used to study molecular and cellular processes, tumor modeling, investigate binding interactions, and as a cell culture supplement, to maintain cell viability.

Application

Heparin lithium was used:
  • To validate photometric measurements in cell surface charge determination
  • As an anti-coagulant for laboratory studies
  • To study hypothermal stress on lactate metabolism[1]
  • To study the effects of anticoagulants in direct membrane feeding assays
  • For 2D and 3D vitro cell culture in glioblastoma cell models[2]
  • To prevent clot formation and tissue damage during mechanical probing of cardiac pacemaker cell embryonic patterning, a study that contributes to the broader area of cardiac tissue mechanics research and developmental biology[3]

Features and Benefits

  • Heparin with specific activity of ≥150 USP units/mg
  • Versatile and adaptable for a wide variety of laboratory and research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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This Item
H6279H5515H3393
Heparin lithium salt from porcine intestinal mucosa ≥150 USP units/mg

Sigma-Aldrich

H0878

Heparin lithium salt from porcine intestinal mucosa

Heparin ammonium salt from porcine intestinal mucosa ≥140 USP units/mg

Sigma-Aldrich

H6279

Heparin ammonium salt from porcine intestinal mucosa

Heparin sodium salt from porcine intestinal mucosa ≥150 IU/mg (dry basis)

Sigma-Aldrich

H5515

Heparin sodium salt from porcine intestinal mucosa

Heparin sodium salt from porcine intestinal mucosa Grade I-A, ≥180 USP units/mg

Sigma-Aldrich

H3393

Heparin sodium salt from porcine intestinal mucosa

biological source

Porcine intestinal mucosa

biological source

Porcine intestinal mucosa

biological source

Porcine intestinal mucosa

biological source

Porcine intestinal mucosa

solubility

water: 40 mg/mL, clear, colorless to faint yellow or tan

solubility

water: 100 mg/mL, clear to hazy, faintly yellow to brownish-yellow

solubility

H2O: 50 mg/mL, clear, colorless to faintly yellow

solubility

H2O: 50 mg/mL, clear, colorless to faintly yellow

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

storage temp.

room temp

storage temp.

-

storage temp.

room temp

storage temp.

room temp

cation traces

Li: 3-4%

cation traces

-

cation traces

-

cation traces

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

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Questions

1–7 of 7 Questions  

  1. Could you provide the procedure for making a 20 IU/mL solution in saline using the H0878-100KU? e.g.) 1) Add 5 Liter of saline in H0878-100KU 1 bottle (volume/weight, %) 2) Vortex thoroughly 3) Filtration (0.2 um pore size) 4) Keep it at 2-4'C

    1 answer

    1. In order to prepare the solution at 20 IU/mL, the activity would be required. The activity of this product is lot specific and reported on the Certificate of Analysis. The minimum activity for any lot would be 150 units/mg. See the link below to review a sample or access the Certificate of a specific lot:
      https://www.sigmaaldrich.com/product/sigma/h0878#product-documentation

      This material is soluble at 40 mg/mL in water. The same rate would be expected in saline, but rates may vary slightly. Stirring is recommended, however vigorous vortexing is not typically required.
      Please see the link below to review the product data sheet which includes information on solubility and solution stability:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/743/456/h0878pis.pdf

      Helpful?

  2. How much heparin is needed to prevent coagulation in whole blood?

    1 answer

    1. It is suggested to use 15 to 30 units per mL of blood.

      Helpful?

  3. There is no expiration date on our heparin lithium salt. The lot # is 76H1236. Is this product usable?

    1 answer

    1. This product is not assigned an expiration date. It is assigned a recommended retest date of roughly 2 years after the quality release date. The lot number given (76H1236) was released in 1996. The contents may demonstrate some activity if the bottle is unopened, however it is unlikely that it would meet specifications. A recommended retest date is the period of time during which the product is expected to remain within established stability specifications, provided that it has been stored under defined conditions. After the Retest Date, product samples should be examined to ensure that the product is still in compliance with the established specifications. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services.

      Helpful?

  4. What is the solution stability of Product H0878, Heparin lithium salt from porcine intestinal mucosa?

    1 answer

    1. Heparin is a polysaccharide, which has excellent aqueous solution stability (up to 2 years at 2-8 °C) provided the solutions have been sterilized by filtration through a 0.2 μm membrane.  More solution stability information can be on the product information sheet (under Documents, above).

      Helpful?

  5. What is the potency of Product H0878, Heparin lithium salt from porcine intestinal mucosa?

    1 answer

    1. The specification for potency is ? 150 USP units/mg.  The lot specific potency can be found on the Certificate of Analysis, which can be accessed on the Product Detail page.

      Helpful?

  6. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  7. How can Product H0878, Heparin lithium salt from porcine intestinal mucosa be reconstituted?

    1 answer

    1. The solubility of heparin is 40 mg/mL in water.

      Helpful?

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