Heparin Cofactor II (HCII) is a member of the serpin superfamily and acts as a serine protease inhibitor. It rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. However, it should be noted that Heparin Cofactor II itself is not a proper anticoagulant. When used alone, it will not prevent blood from coagulating. For anticoagulant purposes, substances such as Heparin sodium salt, EDTA, or Sodium Citrate are commonly used in research and clinical laboratories.
H0417
Heparin Cofactor II from human plasma
aqueous glycerol solution, ≥90% (SDS-PAGE)
Synonym(s):
HCF2, HCII, SERPIND1
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| Size/SKU | Availability | Price |
|---|---|---|
100 μg | Please contact Customer Service for Availability | CZK 18,400.00 |
About This Item
biological source
human plasma
Quality Segment
assay
≥90% (SDS-PAGE)
form
aqueous glycerol solution
mol wt
~66 kDa
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... SERPIND1(3053)
Biochem/physiol Actions
Heparin cofactor II (HCII), a member of the serpin superfamily, is a serine protease inhibitor that rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. In addition to its role in coagulation regulation, HCII may also participate in inflammation, atherosclerosis, and wound repair. For example, leukocyte-mediated degradation of HCII releases peptides that are chemotactic for neutrophils and monocytes which may promote acute inflammation and wound repair. It has also been reported that HCII and dermatan sulfate levels are elevated in pregnancy, suggesting that HCII may be protective against thrombosis during pregnancy.
Serine protease that inhibits thrombin, α-chymotrypsin, neutrophil cathepsin G, and Streptomyces griseus protease B.
Physical form
50% aqueous glycerol solution (vol/vol)
Other Notes
HCII is tested for activity using a Thrombin inhibition assay. One unit will inhibit one NIH unit of Thrombin.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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This Item | |||
|---|---|---|---|
| biological source human plasma | biological source mouse | biological source rabbit | biological source human plasma |
| assay ≥90% (SDS-PAGE) | assay - | assay - | assay ≥95% (SDS-PAGE) |
| Gene Information human ... SERPIND1(3053) | Gene Information human ... SERPIND1(3053) | Gene Information human ... SERPIND1(3053) | Gene Information human ... SERPING1(710) |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level 200 |
| form aqueous glycerol solution | form buffered aqueous solution | form buffered aqueous solution | form aqueous solution |
| shipped in wet ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Will Heparin cofactor II (Sigma H0417) stop blood from coagulating?
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