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Key Documents

GW21024

Sigma-Aldrich

Anti-ADCY6 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Adenylate cyclase type 6, Anti-KIAA0422

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21024

technique(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADCY6(112)

Immunogen

Immunogen Sequence: GI # 10181096, sequence 1-121
Recombinant adenylate cyclase 6 isoform a

Application

Anti-ADCY6 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Adenylate cyclase type 6 is an enzyme encoded by the ADCY6 gene in humans. It is a critical regulator of metabolic and cardiovascular function. It is expressed principally in lipid rafts or caveolae of cardiac myocytes and other cell types. It is localized in lipid rafts of COS-7 cells (expressing caveolin-1). Both the C1 and C2 domains of AC6 play a role in targeting AC6 to lipid rafts.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Muthusamy Thangavel et al.
Cellular signalling, 21(2), 301-308 (2008-11-15)
Previous data has shown that adenylyl cyclase type 6 (AC6) is expressed principally in lipid rafts or caveolae of cardiac myocytes and other cell types while certain other isoforms of AC are excluded from these microdomains. The mechanism by which
Gary J Hodges et al.
The Journal of pharmacology and experimental therapeutics, 335(2), 451-457 (2010-08-25)
Adenylyl cyclase (ADCY) is a critical regulator of metabolic and cardiovascular function. We have identified a genetic variant (A674S) in ADCY isoform 6 (ADCY6). Subsequent studies demonstrated that the expression of this ADCY6 variant paralleled an increase in adenylyl cyclase-mediated

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