G3018

Asialoganglioside GM

from bovine brain, ~98%, cholera toxin inhibitor, lyophilized powder

• Synonym(s): Ceramide tetrahexoside, Ganglioside GM₁, asialo, Gangliotetraosyl ceramide
• CAS Number: 71012-19-6
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00131128
• Assay: ~98%
• Form: lyophilized powder

Properties

• Product Name: Asialoganglioside GM₁ from bovine brain, ~98%, lyophilized powder
• assay: ~98%
• Quality Segment: 200
• form: lyophilized powder
• storage temp.: −20°C
• SMILES string: N([C@H]1[C@@H](O[C@@H]([C@@H]([C@@H]1O[C@@H]4O[C@@H]([C@@H]([C@@H]([C@H]4O)O)O)CO)O)CO)O[C@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H](OC([C@@H]([C@H]3O)O)OCC(NC(=O)CCCCCCCCCCCCCCCCC)C(O)\C=C\CCCCCCCCCCCCC)CO)CO)C(=O)C
• InChI: 1S/C62H114N2O23/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-46(71)64-40(41(70)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)38-80-60-54(78)51(75)57(44(36-67)83-60)86-62-55(79)52(76)56(45(37-68)84-62)85-59-47(63-39(3)69)58(49(73)43(35-66)81-59)87-61-53(77)50(74)48(72)42(34-65)82-61/h30,32,40-45,47-62,65-68,70,72-79H,4-29,31,33-38H2,1-3H3,(H,63,69)(H,64,71)/b32-30+/t40?,41?,42-,43-,44-,45-,47-,48+,49+,50+,51-,52-,53-,54-,55-,56+,57-,58-,59+,60?,61+,62+/m1/s1
• InChI key: VELGMVLNORPMAO-JTFNWEOFSA-N

Description

General description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialylated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Biochem/physiol Actions

Removing the sialic acid from monosialoganglioside GM₁ inhibits its ability to bind cholera toxin. Asialoganglioside GM₁ does not block the binding of cholera toxin to cellular GM₁.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)