G0798
GSK1016790A
≥98% (HPLC), solid, TRPV4 channel agonist
Synonym(s):
GSK101, (N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
10 mg | Please contact Customer Service for Availability | 7 110,00 CZK |
50 mg | Please contact Customer Service for Availability | 27 900,00 CZK 23 715,00 CZK |
About This Item
Product Name
GSK1016790A, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: >10 mg/mL
originator
GlaxoSmithKline
storage temp.
−20°C
SMILES string
CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)N3CCN(CC3)C(=O)[C@H](CO)NS(=O)(=O)c4ccc(Cl)cc4Cl
InChI
1S/C28H32Cl2N4O6S2/c1-17(2)13-21(31-26(36)24-14-18-5-3-4-6-23(18)41-24)27(37)33-9-11-34(12-10-33)28(38)22(16-35)32-42(39,40)25-8-7-19(29)15-20(25)30/h3-8,14-15,17,21-22,32,35H,9-13,16H2,1-2H3,(H,31,36)/t21-,22-/m0/s1
InChI key
IVYQPSHHYIAUFO-VXKWHMMOSA-N
Application
- to stimulate transient receptor potential vanilloid 4 (TRPV4)-mediated currents in Xenopus laevis oocytes
- to stimulate cells in Ca2+ level measurement in human retinal capillary endothelial cells (HRCECs)
- to study the role of TRPV4 channels in brain injury after intracerebral hemorrhage (ICH)
- to trigger the opening of TRPV4 channels in bovine nucleus pulposus cells or Hanks′ Balanced Salt Solution
Biochem/physiol Actions
Features and Benefits
1 of 1
This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description The TRPV4 Antagonist I, RN-1734, also referenced under CAS 946387-07-1, controls the biological activity of TRPV4. This small molecule/inhibitor is primarily used for Biochemicals applications. | description affinity isolated antibody | description targeting mouse Trpv4 |
| form solid | form solid | form buffered aqueous solution | form lyophilized powder |
| assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay - | assay - |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: >10 mg/mL | solubility DMSO: 50 mg/mL | solubility - | solubility - |
| originator GlaxoSmithKline | originator - | originator - | originator - |
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Storage Class
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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