F5178

Flavin-Containing Monooxygenase-5, Microsomes human

recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution (2.5 mg in 100 mM Potassium Phosphate Buffer)

• Synonym(s): FMO-5
• EC Number: 1.14.13.8 (BRENDA, IUBMB)
• NACRES: NA.54
• UNSPSC Code: 12352204
• Specific activity: ≥700 units/mg protein
• Recombinant: expressed in baculovirus infected insect cells

Properties

• recombinant: expressed in baculovirus infected insect cells
• Quality Segment: 200
• form: buffered aqueous solution (2.5 mg in 100 mM Potassium Phosphate Buffer)
• specific activity: ≥700 units/mg protein
• mol wt: 55-60 kDa
• packaging: vial of 2.5 mg
• UniProt accession no.: P49326
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... FMO5(2330)

Description

Application

FMO5 is the only FMO isoform expressed in both adult and fetal human liver.

Biochem/physiol Actions

FMO′s are responsible for catalyzing the oxygenation of a variety of xenobiotic and drug compounds including environmental pollutants and carcinogens, which demonstrate a nucleophilic nitrogen, sulfur, selenium, and phosphorous-containing moiety associated with their respective oxides. These enzymes are classified as Phase I or oxidative drug metabolism enzymes. FMO5 is the only FMO isoform expressed in both adult and fetal human liver.

Physical form

Solution in 100 mM potassium phosphate buffer, pH 7.4.

Other Notes

methyl p-tolyl sulfide oxidase activity: One unit will catalyze the production of 1.0 picomole of methyl p-tolyl sulfoxide.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)