F113
R(−)-Fenfluramine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C12H16F3N · HCl
CAS Number:
Molecular Weight:
267.72
UNSPSC Code:
12352116
PubChem Substance ID:
MDL number:
Pricing and availability is not currently available.
drug control
USDEA Schedule IV
SMILES string
Cl.CCN[C@H](C)Cc1cccc(c1)C(F)(F)F
InChI
1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H/t9-;/m1./s1
InChI key
ZXKXJHAOUFHNAS-SBSPUUFOSA-N
Biochem/physiol Actions
Less active enantiomer
Neurotoxic on prolonged administration or at high dosage; releases serotonin from axon terminals by a nonexocytotic mechanism; anorectic.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Recent studies in the clinical pharmacology of anorectic drugs.
Silverstone, et al.
Recent Adv. Obes. Res., 5, 285-285 (1986)
Benfluorex-induced cardiac valve injury.
Jean Acar
Pharmacoepidemiology and drug safety, 21(11), 1243-1244 (2012-10-31)
Re: Estimate of deaths due to valvular insufficiency attributable to the use of benfluorex in France.
Nicolas Deltour et al.
Pharmacoepidemiology and drug safety, 21(6), 584-585 (2012-04-21)
Geneviève Derumeaux et al.
PloS one, 7(6), e38273-e38273 (2012-06-23)
REGULATE trial was designed to compare the efficacy and safety of benfluorex versus pioglitazone in type 2 diabetes mellitus (DM) patients. Double-blind, parallel-group, international, randomised, non-inferiority trial. More than half of the 196 participating centres were primary care centres. Patients
In the wake of the Mediator scandal: some progress in France, but apathy at the European level.
Prescrire international, 21(126), 110-110 (2012-04-21)
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