F0756

Fusidic acid

Name: Fusidic acid
Brand: SIGMA
Price: 10300 CZK

Antibiotic

Synonym(s):

Ramycin

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1 G

CZK 10,300.00

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About This Item

Empirical Formula (Hill Notation):

C₃₁H₄₈O₆

CAS Number:

6990-06-3

Molecular Weight:

516.71

NACRES:

NA.77

PubChem Substance ID:

57654174

UNSPSC Code:

12352106

EC Number:

230-256-0

MDL number:

MFCD00865135

Quality level:

200

Key Documents

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Product Name

Fusidic acid,

Quality Level

200

storage temp.

2-8°C

SMILES string

[H][C@@]12CC[C@@]3(C)[C@@]([H])([C@H](O)C[C@@]4([H])\C([C@H](C[C@]34C)OC(C)=O)=C(/CC\C=C(\C)C)C(O)=O)[C@@]1(C)CC[C@@H](O)[C@H]2C

InChI

1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1

InChI key

IECPWNUMDGFDKC-MZJAQBGESA-N

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Bioactive Small Molecule Inhibitors

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Show Differences

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This Item	F0881	I1656	C7698
Sigma-Aldrich F0756 Fusidic acid	Sigma-Aldrich F0881 Fusidic acid sodium salt	Sigma-Aldrich I1656 Idarubicin hydrochloride	Sigma-Aldrich C7698 Cycloheximide
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C

Application

Fusidic acid has been used:

as a standard in thin-layer chromatography (TLC)-densitometric method
to study its ability to bind to human serum albumin[1]
as an antibiotic in combination with tannic acid to determine minimum inhibitory concentrations (MIC) in methicillin-resistant Staphylococcus aureus (MRSA)

Biochem/physiol Actions

Fusidic acid is a tetracyclic triterpenoid[2] with antibiotic activity against Gram-positive bacteria.[3] It is derived from Fusidium coccineum. It shows its activity against anaerobes, corynebacterial, Nocardia, and Neisseria species. Fusidic acid exhibits therapeutic effects against Staphylococcal infections, skin infections.[4]

Suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.

Suppresses nitric oxide lysis of pancreatic islet cells; inhibits protein synthesis in prokaryotes.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 + P330 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000498430

0000373558

0000284817

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Characterization of an Acinetobacter baumannii lptD Deletion Strain: Permeability Defects and Response to Inhibition of Lipopolysaccharide and Fatty Acid Biosynthesis.

Jade Bojkovic et al.

Journal of bacteriology, 198(4), 731-741 (2015-12-17)

Lipid A on the Gram-negative outer membrane (OM) is synthesized in the cytoplasm by the Lpx pathway and translocated to the OM by the Lpt pathway. Some Acinetobacter baumannii strains can tolerate the complete loss of lipopolysaccharide (LPS) resulting from

Tannic acid as phytochemical potentiator for antibiotic resistance adaptation

Myint K, et al.

APCBEE procedia, 7, 175-181 (2013)

Amelioration of experimental allergic neuritis by sodium fusidate (fusidin): suppression of IFN-gamma and TNF-alpha and enhancement of IL-10.

R Di Marco et al.

Journal of autoimmunity, 13(2), 187-195 (1999-09-10)

The immunomodulating antibiotic drug fusidic acid and its sodium salt sodium fusidate (fusidin) ameliorate several organ-specific immunoinflammatory diseases. Because preliminary observations suggest that fusidin may also exert a beneficial effect in Guillain-Barré syndrome (GBS), here we have studied the effects

Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB.

Christine Oswald et al.

Nature communications, 7, 13819-13819 (2016-12-17)

The deployment of multidrug efflux pumps is a powerful defence mechanism for Gram-negative bacterial cells when exposed to antimicrobial agents. The major multidrug efflux transport system in Escherichia coli, AcrAB-TolC, is a tripartite system using the proton-motive force as an

Outcome of debridement and retention in prosthetic joint infections by methicillin-resistant staphylococci, with special reference to rifampin and fusidic acid combination therapy.

T N Peel et al.

Antimicrobial agents and chemotherapy, 57(1), 350-355 (2012-11-02)

The management of prosthetic joint infections remains a clinical challenge, particularly infections due to methicillin-resistant staphylococci. Previously, this infection was considered a contraindication to debridement and retention strategies. This retrospective cohort study examined the treatment and outcomes of patients with

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Global Trade Item Number

SKU	GTIN
F0756-1G	04061833611371

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Fusidic acid