E9386

5-Ethyl-2′-deoxyuridine

≥95% (HPLC), synthetic (organic), powder

• Synonym(s): EUdR, Edoxudine
• Empirical Formula (Hill Notation): C₁₁H₁₆N₂O₅
• CAS Number: 15176-29-1
• Molecular Weight: 256.26
• EC Number: 239-226-1
• MDL number: MFCD00079191
• NACRES: NA.51
• PubChem Substance ID: 24894696
• UNSPSC Code: 41106305
• Assay: ≥95% (HPLC)
• Biological source: synthetic (organic)
• Form: powder
• Solubility: water: 50 mg/mL, clear, colorless to yellow
• Storage temp.: −20°C

Properties

• Product Name: 5-Ethyl-2′-deoxyuridine,
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥95% (HPLC)
• form: powder
• solubility: water: 50 mg/mL, clear, colorless to yellow
• storage temp.: −20°C
• SMILES string: CCC1=CN(C2CC(O)C(CO)O2)C(=O)NC1=O
• InChI: 1S/C11H16N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)
• InChI key: XACKNLSZYYIACO-UHFFFAOYSA-N

Description

Biochem/physiol Actions

5-Ethyl-2′-deoxyuridine (EUdR) is used as a 5-fluorouracil (FU) modulator. EtdUrd may be used to enhance the therapeutic index of 5-FU by reducing the catabolism, prolonging the plasma and intratumoral concentrations of 5-FU, and offering protection to normal organs by increasing the endogenous uridine levels.

5-Ethyl-2′-deoxyuridine is an analog of pyrimidine, uridine. It is an effective antiviral agent and inhibits cell division in leukemic tumor cells. 5-Ethyl-2′-deoxyuridine interacts with 2′-deoxycytidine phosphate (dCTP) biosynthesis pathway to elicit antiproliferative effects.

Other Notes

Homolog of thymidine

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)